Baylor College of Medicine, Sleep Disorders and Research Center, Michael E. DeBakey VA Medical Center, Houston TX, USA.
Ther Adv Respir Dis. 2009 Dec;3(6):309-18. doi: 10.1177/1753465809352198. Epub 2009 Oct 30.
Chronic obstructive pulmonary disease (COPD) is a prevalent progressive condition that adversely affects quality of life and sleep. Patients with COPD suffer from variety of sleep disorders including insomnia, sleep disordered breathing and restless leg syndrome. The sleep disorders in COPD patients may stem from poor control of primary disease or due to side effects of pharmacotherapy. Thus, optimization of COPD therapy is the main step in treating insomnia in these patients. Further, pharmacotherapy of sleep disorders may result in respiratory depression and related complications. Therefore, clear understanding of respiratory physiology during transition from wakefulness to sleep and during various stages of sleep plays an important role in therapies that are recommended in patients with significant airway obstruction. In this publication, we review respiratory physiology as it relates to sleep and discuss sleep disorders and their management in patients with COPD.
慢性阻塞性肺疾病（COPD）是一种普遍的进行性疾病，它会对生活质量和睡眠产生不利影响。COPD 患者会患有多种睡眠障碍，包括失眠、睡眠呼吸紊乱和不宁腿综合征。COPD 患者的睡眠障碍可能源于对基础疾病控制不佳，或由于药物治疗的副作用。因此，优化 COPD 治疗是治疗这些患者失眠的主要步骤。此外，睡眠障碍的药物治疗可能导致呼吸抑制和相关并发症。因此，清醒到睡眠过渡以及睡眠各个阶段期间的呼吸生理学的清晰理解在针对有严重气道阻塞的患者的推荐治疗中起着重要作用。在本出版物中，我们综述了与睡眠相关的呼吸生理学，并讨论了 COPD 患者的睡眠障碍及其管理。
