Sexually Transmitted Infections Reference Centre, National Institute for Communicable Diseases of the National Health Laboratory Service, Sandringham, Johannesburg, South Africa.
Sex Transm Infect. 2010 Jun;86(3):175-80. doi: 10.1136/sti.2009.037598. Epub 2009 Nov 1.
To investigate the distribution of human papillomavirus (HPV) genotypes and determine the associations between HPV infection and HIV coinfection in sexually active heterosexual men with anogenital warts (GW), male urethral discharge or asymptomatic men.
Valid specimens for HPV genotyping were obtained from three patient groups consisting of 108 men with GW, 56 men with urethral discharge syndrome and 50 asymptomatic men attending for HIV voluntary counselling and testing. The Linear Array HPV Genotyping Test was used to determine the HPV genotype distribution among study participants. Sera were tested for HIV antibodies using two commercial rapid tests.
The prevalence of anogenital HPV among study participants was 78% (166). HPV DNA was detected in 100% (108) of GW, 48% (27) of men with urethral discharge syndrome and 62% (31) of voluntary counselling and testing participants. HPV types 6, 11, 16 and 18 were prevalent as either single or combined infections in 81% (134) of all HPV-positive study participants. HPV types 6 and/or 11 were significantly higher among GW patients (p<0.001). After adjusting for patient groups, HIV seropositivity was significantly associated with multiple HPV infections (OR=3.98, 95% CI 1.58 to 10.03) but not with the presence of a foreskin (OR=0.67, 95% CI 0.32 to 1.40).
Infections with HPV were prevalent among sexually active heterosexual men attending the men's sexual health clinic. Associations were observed between HIV coinfection and multiple HPV infections. Further population-based studies on the prevalence of HPV genotypes are required to determine if men should be included in any future national HPV vaccination programme in South Africa.
研究人类乳头瘤病毒（HPV）基因型的分布，并确定肛门生殖器疣（GW）、男性尿道分泌物或无症状男性中活跃的异性恋男性 HPV 感染与 HIV 合并感染之间的相关性。
从三组有效标本中获得 HPV 基因分型的有效标本，包括 108 例 GW 男性、56 例尿道分泌物综合征男性和 50 例无症状男性接受 HIV 自愿咨询和检测。线性阵列 HPV 基因分型检测用于确定研究参与者中 HPV 基因型的分布。使用两种商业快速检测法检测血清中的 HIV 抗体。
研究参与者中肛门生殖器 HPV 的患病率为 78%（166 例）。GW 患者中 100%（108 例）、尿道分泌物综合征患者中 48%（27 例）和自愿咨询和检测参与者中 62%（31 例）检测到 HPV DNA。在所有 HPV 阳性研究参与者中，81%（134 例）存在 HPV 6、11、16 和 18 型单一或混合感染。GW 患者中 HPV 6 和/或 11 型明显更高（p<0.001）。调整患者组后，HIV 血清阳性与多种 HPV 感染显著相关（OR=3.98，95%CI 1.58 至 10.03），但与存在包皮无关（OR=0.67，95%CI 0.32 至 1.40）。
在男性性健康诊所就诊的活跃异性恋男性中，HPV 感染很常见。HIV 合并感染与多种 HPV 感染之间存在相关性。需要进一步进行基于人群的 HPV 基因型流行情况研究，以确定南非是否应将男性纳入未来的国家 HPV 疫苗接种计划。
