撒哈拉以南非洲地区女性高危型人乳头瘤病毒的变异性及相关因素：一项系统评价与荟萃分析

Variability of High-Risk Human Papillomavirus and Associated Factors among Women in Sub-Saharan Africa: A Systematic Review and Meta-Analysis.

作者信息

Tchouaket Michel Carlos Tommo, Ka'e Aude Christelle, Semengue Ezechiel Ngoufack Jagni, Sosso Samuel Martin, Simo Rachel Kamgaing, Yagai Bouba, Nka Alex Durand, Chenwi Collins Ambe, Abba Aissatou, Fainguem Nadine, Perno Carlo-Federico, Colizzi Vittorio, Fokam Joseph

机构信息

Chantal BIYA International Reference Centre for Research on HIV/AIDS Prevention and Management, Yaoundé P.O. Box 3077, Cameroon.

School of Health Sciences, Catholic University of Central Africa, Yaoundé P.O. Box 1110, Cameroon.

出版信息

Pathogens. 2023 Aug 11;12(8):1032. doi: 10.3390/pathogens12081032.

BACKGROUND

Sub-Saharan Africa (SSA) carries the highest burden of high-risk human papillomavirus (HR-HPV) in the world, driven by, and together with, HIV infection. This systematic review aimed to identify HR-HPV genotypes and their associated factors among women in SSA.

METHODS

A systematic review and meta-analysis of studies conducted in SSA on HR-HPV was conducted. Standard electronic databases were searched. R software version 3.6.0 was used for meta-analysis, with < 0.05 considered statistically significant.

RESULTS

We included 28 articles with a total of 22,652 participants. The overall pooled prevalence of HR-HPV genotypes was 55.13%, albeit high heterogeneity between studies. The overall pooled prevalence of HR-HPV genotypes in HIV-positive individuals was 75.51%, compared to 52.97% in HIV-negatives (OR = 4.68 (0.71-30.76)). HPV 16 (18%), 35 (10.12%), 52 (9.98%), 18 (9.7%) and 45 (6.82%) genotypes were the most prevalent. Twelve studies identified the most frequently reported risk factors associated with HR-HPV, with HIV infection (66.66%), multiple sexual partners (41.66%) and young age (41.66%) being the most reported risk factors.

CONCLUSIONS

The combined prevalence of HR-HPV genotypes among women in general and HIV-infected women in particular remains high in SSA. The presence of several genotypes not covered by the vaccine is remarkable and suggests the need for revision of current vaccination policies to prevent HR-HPV infections.

背景

在撒哈拉以南非洲（SSA），受艾滋病毒感染的驱动并与之并存，该地区承担着世界上最高的高危型人乳头瘤病毒（HR-HPV）负担。本系统评价旨在确定SSA地区女性中的HR-HPV基因型及其相关因素。

方法

对在SSA地区开展的关于HR-HPV的研究进行系统评价和荟萃分析。检索了标准电子数据库。使用R软件3.6.0版本进行荟萃分析，P<0.05被认为具有统计学意义。

结果

我们纳入了28篇文章，共有22652名参与者。HR-HPV基因型的总体合并患病率为55.13%，尽管研究之间存在高度异质性。HIV阳性个体中HR-HPV基因型的总体合并患病率为75.51%，而HIV阴性个体中为52.97%（比值比=4.68（0.71-30.76））。HPV 16（18%）、35（10.12%）、52（9.98%）、18（9.7%）和45（6.82%）基因型最为常见。12项研究确定了与HR-HPV相关的最常报告的危险因素，其中艾滋病毒感染（66.66%）、多个性伴侣（41.66%）和年轻（41.66%）是最常报告的危险因素。