Division of Critical Care Medicine, Cooper University Hospital, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Camden, NJ 08103, USA.
Crit Care Clin. 2009 Oct;25(4):703-19, vii-viii. doi: 10.1016/j.ccc.2009.08.005.
In this review, we start with a general discussion of relevant factors that can determine the validity of a sepsis animal model. We briefly review some of the currently used animal models of sepsis (small animal models and large animal models). We discuss the clinical relevance of animal models in sepsis research today and address potential reasons for the apparent underperformance of animal models in predicting therapeutic success of novel drugs in clinical trials.
在这篇综述中，我们首先讨论了一些可以确定脓毒症动物模型有效性的相关因素。我们简要回顾了一些目前用于脓毒症的动物模型（小动物模型和大动物模型）。我们讨论了当前脓毒症研究中动物模型的临床相关性，并探讨了动物模型在预测新药临床试验治疗成功率方面表现不佳的潜在原因。
