Zukerberg L R, Rosenberg A E, Randolph G, Pilch B Z, Goodman M L
Department of Pathology, Harvard Medical School, Boston, Massachusetts.
Am J Surg Pathol. 1991 Feb;15(2):126-30. doi: 10.1097/00000478-199102000-00004.
We report two solitary fibrous tumors of the nasal cavity and paranasal sinuses that were histologically and immunohistochemically virtually identical to solitary fibrous tumors (fibrous mesotheliomas) of the pleura. One tumor arose in a 48-year-old woman and the other in a 45-year-old woman. Both patients presented with nasal symptoms, and both patients are alive without evidence of disease 6 months and 1 year after excision. The tumors had a disorganized or "patternless" arrangement of spindle cells in a collagenous background and prominent vascular channels of varying size. Immunoperoxidase stains on paraffin sections showed staining of the cells for vimentin only; there was no staining for keratin, S-100 protein, desmin, and actin. Both cases presented some degree of diagnostic difficulty and had to be distinguished from other spindle cell tumors of the nasal cavity and paranasal sinuses, such as hemangiopericytoma, angiofibroma, and fibrous histiocytoma.
我们报告了两例鼻腔及鼻窦孤立性纤维瘤，其组织学和免疫组织化学特征与胸膜孤立性纤维瘤（纤维性间皮瘤）几乎完全相同。其中一例发生于一名48岁女性，另一例发生于一名45岁女性。两名患者均表现出鼻部症状，且在切除术后6个月和1年时均存活，无疾病迹象。肿瘤在胶原背景中呈现梭形细胞排列紊乱或“无模式”，并有大小不一的显著血管通道。石蜡切片免疫过氧化物酶染色显示细胞仅波形蛋白染色阳性；角蛋白、S-100蛋白、结蛋白和肌动蛋白均无染色。两例病例在诊断上均存在一定困难，必须与鼻腔及鼻窦的其他梭形细胞肿瘤相鉴别，如血管外皮细胞瘤、血管纤维瘤和纤维组织细胞瘤。
