Tanida Mamoru, Tsuruoka Nobuo, Shen Jiao, Horii Yuko, Beppu Yoshinori, Kiso Yoshinobu, Nagai Katsuya
Institute for Protein Research, Osaka University, Suita, Osaka, Japan.
Biosci Biotechnol Biochem. 2009 Nov;73(11):2374-8. doi: 10.1271/bbb.90196. Epub 2009 Nov 7.
In a previous report, evidence was presented that flavangenol supplementation has an anti-ischemic effects in rats. In the study presented here, we examined the autonomic effects of intraduodenal (ID) injection of flavangenol in urethane-anesthetized rats and found that it increased sympathetic nerve activity innervating brown adipose tissue (BAT-SNA) in a dose-dependent manner, while it suppressed gastric vagal nerve activity (GVNA). In addition, intra-oral (IO) injection of flavangenol elevated brown adipose tissue temperature (BAT-T). Furthermore, flavangenol drinking for 15 d reduced body weight gain in rats fed a high-fat diet. These results thus suggest that flavangenol supplementation exerts its reducing action on body weight through changes in autonomic neurotransmission.
在之前的一份报告中，有证据表明补充黄烷醇对大鼠具有抗缺血作用。在本文所呈现的研究中，我们检测了在乌拉坦麻醉的大鼠中十二指肠内（ID）注射黄烷醇的自主神经效应，发现它以剂量依赖性方式增加支配棕色脂肪组织的交感神经活动（BAT-SNA），同时抑制胃迷走神经活动（GVNA）。此外，经口（IO）注射黄烷醇可提高棕色脂肪组织温度（BAT-T）。此外，连续15天饮用含黄烷醇的饮品可减少高脂饮食喂养大鼠的体重增加。因此，这些结果表明补充黄烷醇通过自主神经传递的变化对体重发挥减轻作用。
