Zhang Xuejun, Li Xin, Fang Huang, Guo Fengjin, Li Feng, Chen Anmin, Huang Shilong
Department of Orthopedics, First People's Hospital of Yichang, No.4 Hudi Street, Yichang, 443000 Hubei Province China.
2Department of Pediatrics, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No.1277 Jie Fang Avenue, Wuhan, 430022 Hubei Province China.
Nutr Metab (Lond). 2019 Jul 18;16:47. doi: 10.1186/s12986-019-0370-7. eCollection 2019.
Flavonoids are a class of plant and fungus secondary metabolites and are the most common group of polyphenolic compounds in the human diet. In recent studies, flavonoids have been shown to induce browning of white adipocytes, increase energy consumption, inhibit high-fat diet (HFD)-induced obesity and improve metabolic status. Promoting the activity of brown adipose tissue (BAT) and inducing white adipose tissue (WAT) browning are promising means to increase energy expenditure and improve glucose and lipid metabolism. This review summarizes recent advances in the knowledge of flavonoid compounds and their metabolites.
We searched the following databases for all research related to flavonoids and WAT browning published through March 2019: PubMed, MEDLINE, EMBASE, and the Web of Science. All included studies are summarized and listed in Table 1.
We summarized the effects of flavonoids on fat metabolism and the specific underlying mechanisms in sub-categories. Flavonoids activated the sympathetic nervous system (SNS), promoted the release of adrenaline and thyroid hormones to increase thermogenesis and induced WAT browning through the AMPK-PGC-1α/Sirt1 and PPAR signalling pathways. Flavonoids may also promote brown preadipocyte differentiation, inhibit apoptosis and produce inflammatory factors in BAT.
Flavonoids induced WAT browning and activated BAT to increase energy consumption and non-shivering thermogenesis, thus inhibiting weight gain and preventing metabolic diseases.
黄酮类化合物是一类植物和真菌的次生代谢产物，是人类饮食中最常见的多酚类化合物。在最近的研究中，黄酮类化合物已被证明可诱导白色脂肪细胞褐变，增加能量消耗，抑制高脂饮食（HFD）诱导的肥胖并改善代谢状态。促进棕色脂肪组织（BAT）的活性和诱导白色脂肪组织（WAT）褐变是增加能量消耗以及改善葡萄糖和脂质代谢的有前景的方法。本综述总结了黄酮类化合物及其代谢产物的最新研究进展。
我们在以下数据库中检索了截至2019年3月发表的所有与黄酮类化合物和WAT褐变相关的研究：PubMed、MEDLINE、EMBASE和科学网。所有纳入研究总结并列于表1中。
我们在子类别中总结了黄酮类化合物对脂肪代谢的影响及其具体潜在机制。黄酮类化合物激活交感神经系统（SNS），促进肾上腺素和甲状腺激素的释放以增加产热，并通过AMPK-PGC-1α/Sirt1和PPAR信号通路诱导WAT褐变。黄酮类化合物还可能促进棕色前脂肪细胞分化，抑制BAT中的细胞凋亡并产生炎症因子。
黄酮类化合物诱导WAT褐变并激活BAT以增加能量消耗和非寒战产热，从而抑制体重增加并预防代谢疾病。
