Taylor M J, Godfrey E, Baczko K, ter Meulen V, Wild T F, Rima B K
Division of Genetic Engineering, Queen's University of Belfast, U.K.
J Gen Virol. 1991 Jan;72 ( Pt 1):83-8. doi: 10.1099/0022-1317-72-1-83.
The sequences of a region of the nucleocapsid protein gene, between nucleotides 1231 and 1686, encoding the C-terminal 151 amino acid residues of the nucleocapsid protein have been determined for 16 strains of measles virus. Analysis of this region showed that it is highly divergent (up to 7.2% divergence in the nucleotide sequence and 10.6% divergence in the amino acid sequence between most distant strains) and that several lineages of measles virus can be found to co-circulate at a given time. Some of the lineages show geographical restriction. The results for measles virus are similar to those reported for other human paramyxoviruses such as mumps virus, parainfluenza type 3 virus and the avian Newcastle disease virus.
已测定了16株麻疹病毒核衣壳蛋白基因一个区域(核苷酸1231至1686之间)的序列,该区域编码核衣壳蛋白的C端151个氨基酸残基。对该区域的分析表明,它具有高度的差异性(在最远距离的毒株之间,核苷酸序列差异高达7.2%,氨基酸序列差异高达10.6%),并且在特定时间可以发现几种麻疹病毒谱系共同传播。其中一些谱系显示出地理局限性。麻疹病毒的结果与其他人类副粘病毒(如腮腺炎病毒、3型副流感病毒和禽新城疫病毒)的报道结果相似。