Department of Family Medicine and Community Health, University of Pennsylvania School of Medicine, 2nd Floor Gates Pavilion, 3400 Spruce St, Philadelphia, PA 19104-4283, USA.
Ann Fam Med. 2009 Nov-Dec;7(6):527-33. doi: 10.1370/afm.1051.
Clinical innovations have made it more feasible to incorporate early abortion into family medicine, yet the outcomes of early abortion procedures in this setting have not been well studied. We wished to assess the outcomes of first-trimester medication and aspiration abortion procedures by family physicians.
Prospective observational cohort study conducted from August 2001 to February 2005 of 2,550 women who sought pregnancy termination in 4 clinical practices of family medicine departments and 1 private office/training site.
The rate of successful uncomplicated procedures for medication was 96.5% (95.5%-97.1% [corrected] confidence interval [CI], 95.5%-97.0%) and for aspiration was 99.9% (CI, 99.3%-1). Adverse events and complications of medication abortions were failed procedure (ongoing pregnancy; n = 19, 1.45%); incomplete abortion (n = 16, 1.22%); hemorrhage (n = 9, 0.69%); and patient request for aspiration (n = 1, 0.08%). One (0.08%) missed ectopic pregnancy was seen among patients receiving medication. Four types of adverse outcomes were encountered with aspiration: incomplete abortion requiring re-aspiration (n = 21, 1.83%); hemorrhage during the procedure (n = 4, 0.35%); missed ectopic pregnancy (n = 3, 0.26%); and minor endometritis (n = 1, 0.09%). Missed ectopic pregnancies were successfully treated in the inpatient setting without mortality (overall hospitalization rate of 0.16 of 100). All other complications were managed within outpatient family medicine sites. Rates of complication did not vary by experience of physician or by site of care (residency vs private practice).
Complications of medication and aspiration procedures occurred at a low rate, and most were minor and managed without incident.
临床创新使得将早期堕胎纳入家庭医学实践变得更加可行,但这种环境下早期堕胎程序的结果尚未得到很好的研究。我们希望评估家庭医生进行的早期妊娠药物和吸引流产程序的结果。
2001 年 8 月至 2005 年 2 月,在 4 个家庭医学科临床实践和 1 个私人诊所/培训点进行了前瞻性观察队列研究,共纳入 2550 名寻求终止妊娠的女性。
药物流产的成功率为 96.5%(95.5%-97.1%[校正]置信区间[CI],95.5%-97.0%),吸引流产的成功率为 99.9%(CI,99.3%-1%)。药物流产的不良事件和并发症包括手术失败(持续性妊娠;n=19,1.45%);不完全流产(n=16,1.22%);出血(n=9,0.69%);以及患者要求进行吸引(n=1,0.08%)。接受药物治疗的患者中发现 1 例(0.08%)漏诊异位妊娠。吸引术有 4 种不良后果:需要再次吸引的不完全流产(n=21,1.83%);术中出血(n=4,0.35%);漏诊异位妊娠(n=3,0.26%);以及轻微子宫内膜炎(n=1,0.09%)。所有漏诊的异位妊娠均在住院治疗,无死亡(总住院率为每 100 例 0.16 例)。所有其他并发症均在家庭医学门诊站点得到处理。并发症的发生率与医生的经验或护理地点无关(住院医师与私人执业)。
药物和吸引术的并发症发生率较低,大多数为轻微并发症,无需住院治疗。