Lysons R J, Kent K A, Bland A P, Sellwood R, Robinson W F, Frost A J
AFRC Institute for Animal Health, Compton Laboratory, Newbury, Berkshire.
J Med Microbiol. 1991 Feb;34(2):97-102. doi: 10.1099/00222615-34-2-97.
The haemolysin from a virulent strain of Treponema hyodysenteriae was extracted and injected into ligated loops of the ileum and colon of germ-free pigs. It caused severe epithelial damage, especially to the differentiated cells at the tips of the villi in the ileum and the cells in the intercrypt zones of the colon; goblet cells were less affected. The changes in the colon were similar to those seen in natural cases of swine dysentery. The ligated loop offers a means of investigating pathogenic mechanisms and the mode of action of the toxin. This study demonstrated that the haemolysin was a potent cytotoxin for pig enterocytes, and a probable virulence determinant in swine dysentery.
从强毒猪痢疾密螺旋体菌株中提取溶血素，并将其注射到无菌猪的回肠和结肠的结扎肠袢中。它引起了严重的上皮损伤，尤其是对回肠绒毛尖端的分化细胞和结肠隐窝间区域的细胞；杯状细胞受影响较小。结肠中的变化与猪痢疾自然病例中所见的变化相似。结扎肠袢提供了一种研究致病机制和毒素作用方式的方法。这项研究表明，溶血素是猪肠上皮细胞的一种强效细胞毒素，并且可能是猪痢疾中的一种毒力决定因素。
