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一项关于在接受6兆伏外部X射线束治疗的孕妇中用于减少胎儿泄漏和散射辐射的屏蔽的研究。

A study of the shielding used to reduce leakage and scattered radiation to the fetus in a pregnant patient treated with a 6-MV external X-ray beam.

作者信息

Han Bin, Bednarz Bryan, Xu X George

机构信息

Nuclear Engineering and Engineering Physics, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.

出版信息

Health Phys. 2009 Dec;97(6):581-9. doi: 10.1097/01.HP.0000363838.70546.4c.

DOI:10.1097/01.HP.0000363838.70546.4c
PMID:19901592
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3376892/
Abstract

A Monte Carlo-based procedure has been developed to assess the shielded fetal doses from 6 MV external photon beam radiation treatments and improve upon existing techniques that are based on AAPM Task Group Report 36 (TG-36). Anatomically realistic models of the pregnant patient representing 3- and 6-mo gestational stages were implemented into the MCNPX code together with a detailed accelerator model that is capable of simulating scattered and leakage radiation from the accelerator head. The phantom was shielded using suggested lead and Cerrobend in different locations and with different thicknesses. Absorbed doses to the fetus both with and without shielding were calculated considering typical mantle, head and neck, and brain treatment plans. The unshielded fetal doses tended to increase with decreasing distance from the field edge to the nearest fetal point and increasing of the field size. The unshielded absorbed doses to the fetus for all treatment plans ranged from a maximum of 4.08 microGy/MU (monitor unit) to a minimum 0.09 microGy/MU. The use of lead or Cerrobend shielding reduced the fetal doses by factors of up to 4. For an optimal shield half-value layer, the dose reduction between lead and Cerrobend was statistically insignificant. The maximum permitted MUs for the mantle treatments with shielding were calculated based on 5 cGy dose limits suggested by TG-36. The study demonstrates an accurate assessing tool that can be used to determine the absorbed dose to the fetus and to design the shielding as part of the treatment planning and risk management.

摘要

已开发出一种基于蒙特卡罗方法的程序,用于评估6兆伏外部光子束放射治疗中胎儿的屏蔽剂量,并改进基于美国医学物理学家协会任务组报告36(TG - 36)的现有技术。将代表妊娠3个月和6个月阶段的孕妇解剖学逼真模型与能够模拟加速器头部散射和泄漏辐射的详细加速器模型一起应用于MCNPX代码中。使用建议的铅和铈铋在不同位置和不同厚度对体模进行屏蔽。考虑典型的斗篷野、头颈部和脑部治疗计划,计算有无屏蔽时胎儿的吸收剂量。未屏蔽时,胎儿剂量往往随着从射野边缘到最近胎儿点的距离减小以及射野尺寸增大而增加。所有治疗计划中胎儿未屏蔽时的吸收剂量范围为最大4.08微戈瑞/监测单位(MU)至最小0.09微戈瑞/MU。使用铅或铈铋屏蔽可使胎儿剂量降低多达4倍。对于最佳屏蔽半值层,铅和铈铋之间的剂量降低在统计学上无显著差异。根据TG - 36建议的5厘戈瑞剂量限值,计算了有屏蔽时斗篷野治疗允许的最大MU。该研究展示了一种准确的评估工具,可用于确定胎儿的吸收剂量,并作为治疗计划和风险管理的一部分设计屏蔽措施。

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本文引用的文献

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A feasibility study to calculate unshielded fetal doses to pregnant patients in 6-MV photon treatments using Monte Carlo methods and anatomically realistic phantoms.一项使用蒙特卡罗方法和解剖学逼真体模计算6兆伏光子治疗中孕妇患者未屏蔽胎儿剂量的可行性研究。
Med Phys. 2008 Jul;35(7):3054-61. doi: 10.1118/1.2938519.
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A boundary-representation method for designing whole-body radiation dosimetry models: pregnant females at the ends of three gestational periods--RPI-P3, -P6 and -P9.一种用于设计全身辐射剂量测定模型的边界表示方法:处于三个妊娠期末期的孕妇——RPI-P3、-P6和-P9。
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Med Phys. 2007 Apr;34(4):1193-7. doi: 10.1118/1.2710332.
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A Monte Carlo model for calculating out-of-field dose from a varian 6 MV beam.一种用于计算瓦里安6兆伏(MV)射线束野外剂量的蒙特卡罗模型。
Med Phys. 2006 Nov;33(11):4405-13. doi: 10.1118/1.2360013.
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Radiotherapy for a solitary brain metastasis during pregnancy: a method for reducing fetal dose.孕期孤立性脑转移瘤的放射治疗:一种降低胎儿剂量的方法。
Br J Radiol. 2001 Jul;74(883):638-41. doi: 10.1259/bjr.74.883.740638.
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A simplified shielding approach for limiting fetal dose during radiation therapy of pregnant patients.一种在孕妇放射治疗期间限制胎儿剂量的简化屏蔽方法。
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Shielding for neutron scattered dose to the fetus in patients treated with 18 MV x-ray beams.18兆伏X射线束治疗患者中胎儿所受中子散射剂量的防护。
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