Cancer Epidemiology and Prevention Research Group, Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland, UK.
Prostate Cancer Prostatic Dis. 2009;12(4):325-32. doi: 10.1038/pcan.2009.38. Epub 2009 Sep 1.
Lycopene has a chemopreventive effect against prostate cancer but its role in prostate cancer progression is unknown; many patients increase their intake of lycopene, although there are no evidence-based guidelines to suggest an effect. Our objective was to conduct a systematic review of literature to evaluate the association between lycopene intake and prostate cancer progression. MEDLINE, EMBASE CINAHL Plus, Web of Science, AMED and CENTRAL databases were systematically searched using terms for lycopene and prostate cancer progression to identify studies published before January 2009. Eight intervention studies were identified (five with no control group; one with an unmatched control group; and two randomized controlled trials (RCTs)). An inverse association was observed between lycopene intake and PSA levels in six studies. The rates of progression measured by bone scan in one RCT were lower in the intervention group. Lycopene resulted in lowering cancer-related symptoms (pain, urinary tract symptoms), and severe toxicity or intolerance was not evident. However, the evidence available to date is insufficient to draw a firm conclusion with respect to lycopene supplementation in prostate cancer patients and larger RCTs are required in broader patient groups.
番茄红素对前列腺癌具有化学预防作用，但它在前列腺癌进展中的作用尚不清楚；许多患者增加了番茄红素的摄入量，尽管没有基于证据的指南表明其有效果。我们的目的是对文献进行系统综述，以评估番茄红素摄入与前列腺癌进展之间的关系。使用番茄红素和前列腺癌进展的术语，对 MEDLINE、EMBASE CINAHL Plus、Web of Science、AMED 和 CENTRAL 数据库进行了系统检索，以确定在 2009 年 1 月之前发表的研究。确定了 8 项干预研究（5 项无对照组；1 项无匹配对照组；2 项随机对照试验（RCT））。在 6 项研究中，观察到番茄红素摄入量与 PSA 水平之间呈负相关。一项 RCT 中通过骨扫描测量的进展率在干预组中较低。番茄红素可降低癌症相关症状（疼痛、尿路症状），且未见严重毒性或不耐受。然而，目前的证据还不足以得出关于前列腺癌患者补充番茄红素的明确结论，需要在更广泛的患者群体中开展更大规模的 RCT。
