Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, GR-41334 Larissa, Greece.
Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, University Campus, GR-54124 Thessaloniki, Greece.
Nutrients. 2020 Sep 29;12(10):2985. doi: 10.3390/nu12102985.
The quest for dietary patterns and supplements efficient in down-regulating prostate-specific antigen (PSA) concentrations among men with prostate cancer (PCa) or increased PCa risk has been long. Several antioxidants, including lycopene, selenium, curcumin, coenzyme Q10, phytoestrogens (including isoflavones and flavonoids), green tea catechins, cernitin, vitamins (C, E, D) and multivitamins, medicinal mushrooms (), fruit extracts (saw palmetto, cranberries, pomegranate), walnuts and fatty acids, as well as combined supplementations of all, have been examined in randomized controlled trials (RCTs) in humans, on the primary, secondary, and tertiary PCa prevention level. Despite the plethora of trials and the variety of examined interventions, the evidence supporting the efficacy of most dietary factors appears inadequate to recommend their use.
长期以来，人们一直在寻找能够有效降低前列腺癌（PCa）或有 PCa 风险男性的前列腺特异性抗原（PSA）浓度的饮食模式和补充剂。几种抗氧化剂，包括番茄红素、硒、姜黄素、辅酶 Q10、植物雌激素（包括异黄酮和类黄酮）、绿茶儿茶素、芹菜素、维生素（C、E、D）和多种维生素、药用蘑菇（）、水果提取物（锯棕榈、蔓越莓、石榴）、核桃和脂肪酸，以及所有这些的联合补充剂，已在人类的随机对照试验（RCT）中进行了检查，以预防原发性、继发性和三级 PCa。尽管试验数量众多，检查的干预措施种类繁多，但支持大多数饮食因素有效性的证据似乎不足以推荐其使用。
