调控出错：一部分蕈样肉芽肿患者存在恶性调节性T细胞。
Regulation gone wrong: a subset of Sézary patients have malignant regulatory T cells.
作者信息
Clark Rachael A
机构信息
Harvard Skin Disease Research Center and the Department of Dermatology, Brigham and Women's Hospital, EBRC Room 505A, 221 Longwood Avenue, Boston, Massachusetts 02115, USA.
出版信息
J Invest Dermatol. 2009 Dec;129(12):2747-50. doi: 10.1038/jid.2009.290.
Abstract
Cutaneous T-cell lymphomas (CTCLs) are non-Hodgkin's lymphomas derived from T cells that home to and inhabit the skin. There are conflicting reports as to whether CTCLs represent a malignancy of regulatory T cells (Tregs), a T-cell subset that can suppress local immune reactions. In this issue, Heid et al. present convincing evidence that the malignant T cells in a subgroup of Sézary patients are FOXP3(+) regulatory T cells. Clonal malignant T cells showed increased expression of the Treg-associated transcription factor FOXP3 and demethylation of the FOXP3 gene locus, and T cells from at least some of these patients suppressed T-cell proliferation in vitro.
摘要
皮肤T细胞淋巴瘤（CTCLs）是非霍奇金淋巴瘤，源自归巢并定居于皮肤的T细胞。关于CTCLs是否代表调节性T细胞（Tregs）的恶性肿瘤存在相互矛盾的报道，调节性T细胞是一种可抑制局部免疫反应的T细胞亚群。在本期杂志中，海德等人提供了令人信服的证据，表明蕈样肉芽肿患者亚组中的恶性T细胞是FOXP3（+）调节性T细胞。克隆性恶性T细胞显示出Treg相关转录因子FOXP3的表达增加以及FOXP3基因座的去甲基化，并且来自这些患者中至少一些患者的T细胞在体外抑制T细胞增殖。
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