致痫剂在对地西泮耐受大鼠中的作用特异性
Specificity of action of epileptogenic agents in diazepam-tolerant rats.
作者信息
Kresyun V I, Godlevskii L S, Kobolev E V
机构信息
Odessa State Medical University, Ukraine.
出版信息
Bull Exp Biol Med. 2009 Jun;147(6):719-21. doi: 10.1007/s10517-009-0597-9.
PMID:19902066
Abstract
The development of tolerance in rats by repeated intraperitoneal injection of 0.5 mg/kg diazepam increased the sensitivity of the frontal cortex to the epileptogenic effect of NMDA and kainic acid. The median effective dose of NMDA was shown to decrease under these conditions. Intracerebroventricular injection of NMDA in these doses induced clonic seizures and tonic extension of the forelimbs.
摘要
通过腹腔内重复注射0.5毫克/千克地西泮使大鼠产生耐受性，增加了额叶皮质对N-甲基-D-天冬氨酸（NMDA）和红藻氨酸致痫作用的敏感性。在这些条件下，NMDA的半数有效剂量降低。以这些剂量脑室内注射NMDA可诱发阵挛性惊厥和前肢强直性伸展。
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