一种用于定量脑电图评估具有惊厥和抗惊厥特性药物的简单方法。

A simple method for quantitative electroencephalographic assessment of drugs with convulsant and anticonvulsant properties.

作者信息

Zaczek R, Markl A, Balm M, Coyle J T

出版信息

J Neurosci Methods. 1986 Dec;18(4):351-60. doi: 10.1016/0165-0270(86)90023-3.

Abstract

A simple, inexpensive and reliable microcomputer-assisted method to detect and quantify abnormal EEG spiking is described. High frequency wave forms (20-40 Hz) with high amplitude are discriminated using a beta-2 bandpass filter and a threshold comparater. The spikes are then compiled and reported by an Apple II+ microcomputer. The method was validated by measuring seizures generated by intraperitoneal injection of pentylenetetrazol (PTZ), by microinjection of excitatory amino acids into the dorsal hippocampus, and by the antagonism of these seizures by diazepam and 2-amino-7-phosphono heptanoic acid, respectively.

摘要

本文描述了一种简单、廉价且可靠的微机辅助方法，用于检测和量化异常脑电图尖峰。使用β-2带通滤波器和阈值比较器来区分高振幅的高频波形（20-40赫兹）。然后由一台Apple II+微机对尖峰进行汇总并报告。该方法通过测量腹腔注射戊四氮（PTZ）、向背侧海马体微量注射兴奋性氨基酸所引发的癫痫发作，以及分别用安定和2-氨基-7-膦酰庚酸对这些癫痫发作的拮抗作用进行了验证。