阿伏苯唑与σ1受体的相互作用。
Interaction of afobazole with sigma1-receptors.
作者信息
Seredenin S B, Antipova T A, Voronin M V, Kurchashova S Yu, Kuimov A N
机构信息
V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, M. V. Lomonosov Moscow State University, Russia.
出版信息
Bull Exp Biol Med. 2009 Jul;148(1):42-4. doi: 10.1007/s10517-009-0624-x.
In vitro radioligand assay revealed interaction of afobazole with sigma(1)-receptors (Ki=5.9x10(-6) M). Translocation of sigma(1)-receptors from the endoplasmic reticulum to the outer membrane was demonstrated by confocal microscopy. Experiments were performed on the model of HT-22 immortalized hippocampal cells after incubation with afobazole in a concentration of 10(-8) M.
体外放射性配体测定显示阿福唑与σ1受体相互作用（Ki = 5.9×10⁻⁶ M）。共聚焦显微镜证实了σ1受体从内质网向内质网膜的转位。在用浓度为10⁻⁸ M的阿福唑孵育后，在HT - 22永生化海马细胞模型上进行了实验。
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