V. V. Zakusov Research Institute of Pharmacology, Moscow, Russia.
Bull Exp Biol Med. 2020 Oct;169(6):783-786. doi: 10.1007/s10517-020-04978-4. Epub 2020 Oct 24.
Previous in vitro and in vivo studies revealed the neuroprotective effect of anxiolytic Afobazole. Based on similarities in the regulation of functions of neurons and β cells, we studied the effect of Afobazole on streptozotocin (STZ) model of type 2 diabetes in Wistar rats. Immunohistochemical analysis showed that the decrease in the number of β cells and a violation of their morphological structure caused by STZ were significantly alleviated by Afobazole administration (10 mg/kg orally for 28 days) to diabetic animals. A correlation between morphometric data and blood glucose level was revealed. A possible role of σ-receptors in the cytoprotective effects of Afobazole in respect to pancreatic β cells is discussed.
先前的体外和体内研究揭示了抗焦虑药阿普唑仑的神经保护作用。基于神经元和β细胞功能调节的相似性，我们研究了阿普唑仑对 Wistar 大鼠 2 型糖尿病链脲佐菌素（STZ）模型的影响。免疫组织化学分析表明，STZ 引起的β细胞数量减少和形态结构破坏，经阿普唑仑（10mg/kg 口服，28 天）给药至糖尿病动物后显著减轻。还揭示了形态计量学数据与血糖水平之间的相关性。讨论了 σ-受体在阿普唑仑对胰腺β细胞的细胞保护作用中的可能作用。
