Digestive System Research Unit, Hospital Universitari Vall d'Hebron, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Barcelona 08035, Spain.
Int J Colorectal Dis. 2010 Apr;25(4):485-9. doi: 10.1007/s00384-009-0832-x. Epub 2009 Nov 10.
Hydrogen breath test is the most commonly used method to analyze carbohydrate absorption and diagnose carbohydrate malabsorption. The result of the H(2) breath test is influenced by different factors, which are mostly related to quantitative or qualitative aspects of colonic flora. A scarcely studied variable is the effect of colonic anatomical integrity on H(2) excretion in breath.
The present study aims to determine whether loss of colonic integrity reduces H(2) excretion capacity after an oral load of an unabsorbable carbohydrate.
An observational study was conducted in three patient groups: controls with preserved colon, patients with partial colectomy, and patients with complete colectomy and ileostomy. H(2) concentration in breath was measured by gas chromatography every 10 min for 3 h after oral lactulose administration.
Twenty-two patients with partial colectomy, 18 controls with preserved colon, and seven patients with ileostomy were included. H(2) excretion after lactulose did not differ between patients with partial colectomy and controls (basal excretion = 8.5 vs 4 ppm; delta increase = 50.0 vs 47.5 ppm; area under the curve = 4,480.0 vs 4,710.5 ppm/min). In contrast, H(2) excretion was significantly lower in the ileostomy group.
Partial colectomy does not influence the capacity for H(2) excretion after oral unabsorbable carbohydrate administration.
氢气呼气试验是分析碳水化合物吸收和诊断碳水化合物吸收不良最常用的方法。H（2）呼气试验的结果受多种因素影响，这些因素主要与结肠菌群的定量或定性方面有关。一个研究甚少的变量是结肠解剖完整性对呼气中 H（2）排泄的影响。
本研究旨在确定结肠完整性丧失是否会降低口服不可吸收碳水化合物后 H（2）的排泄能力。
在三组患者中进行了一项观察性研究：保留结肠的对照组、部分结肠切除术患者组和完全结肠切除术加回肠造口术患者组。口服乳果糖后，通过气相色谱法每 10 分钟测量一次呼吸中的 H（2）浓度，持续 3 小时。
纳入了 22 例部分结肠切除术患者、18 例保留结肠的对照组和 7 例回肠造口术患者。部分结肠切除术患者和对照组的乳果糖后 H（2）排泄没有差异（基础排泄=8.5 vs 4 ppm；增加量=50.0 vs 47.5 ppm；曲线下面积=4,480.0 vs 4,710.5 ppm/min）。相比之下，回肠造口术组的 H（2）排泄明显较低。
部分结肠切除术不会影响口服不可吸收碳水化合物后 H（2）的排泄能力。
