Cotter A, Lambert J, O'Gorman P
Department Infectious Diseases, Mater Misericordiae University Hospital, Eccles St., Dublin 7 and University College Dublin, School of Medicine & Medical Sciences, Dublin.
Ir Med J. 2009 Oct;102(9):294-5.
We report the case of a 35 year patient from Nigeria who presented with fever and splenomegaly. The initial diagnosis was Salmonellosis. However, relapsing symptoms lead to a re-evaluation and ultimately a diagnosis of Multicentric Castleman's Disease (MCD). There is no gold standard treatment but our patient responded to Rituximab and Highly active anti-retroviral therapy. MCD is a rare, aggressive disease that should be considered in a HIV positive patient presenting with fever and significant lymphadenopathy.
我们报告了一名来自尼日利亚的35岁患者的病例，该患者出现发热和脾肿大。初步诊断为沙门氏菌病。然而，症状复发导致重新评估，最终诊断为多中心Castleman病（MCD）。目前尚无金标准治疗方法，但我们的患者对利妥昔单抗和高效抗逆转录病毒疗法有反应。MCD是一种罕见的侵袭性疾病，对于出现发热和明显淋巴结病的HIV阳性患者应予以考虑。
