• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

B细胞和心肌细胞特异性E2盒结合因子含有E12/E47样亚基。

B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits.

作者信息

Murre C, Voronova A, Baltimore D

机构信息

Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142.

出版信息

Mol Cell Biol. 1991 Feb;11(2):1156-60. doi: 10.1128/mcb.11.2.1156-1160.1991.

DOI:10.1128/mcb.11.2.1156-1160.1991
PMID:1990271
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC359799/
Abstract

Recent studies have identified a family of DNA-binding proteins that share a common DNA-binding and dimerization domain with the potential to form a helix-loop-helix (HLH) structure. Various HLH proteins can form heterodimers that bind to a common DNA sequence, termed the E2-box. We demonstrate here that E2-box-binding B-cell- and myocyte-specific nuclear factors contain subunits which are identical or closely related to ubiquitously expressed (E12/E47) HLH proteins. These biochemical function for E12/E47-like molecules in mammalian differentiation, similar to the genetically defined function of daughterless in Drosophila development.

摘要

最近的研究鉴定出了一类DNA结合蛋白家族，它们具有共同的DNA结合和二聚化结构域，有可能形成螺旋-环-螺旋（HLH）结构。各种HLH蛋白可以形成异源二聚体，这些异源二聚体结合到一个共同的DNA序列上，该序列被称为E2盒。我们在此证明，结合E2盒的B细胞和肌细胞特异性核因子包含与普遍表达的（E12/E47）HLH蛋白相同或密切相关的亚基。这些E12/E47样分子在哺乳动物分化中的生化功能，类似于果蝇发育中无女儿基因所定义的功能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1f/359799/5aa89c498656/molcellb00137-0585-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1f/359799/761494c65607/molcellb00137-0583-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1f/359799/6b8962b176f1/molcellb00137-0584-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1f/359799/6e16d60e3694/molcellb00137-0584-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1f/359799/5aa89c498656/molcellb00137-0585-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1f/359799/761494c65607/molcellb00137-0583-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1f/359799/6b8962b176f1/molcellb00137-0584-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1f/359799/6e16d60e3694/molcellb00137-0584-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b1f/359799/5aa89c498656/molcellb00137-0585-a.jpg

相似文献

1
B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits.B细胞和心肌细胞特异性E2盒结合因子含有E12/E47样亚基。
Mol Cell Biol. 1991 Feb;11(2):1156-60. doi: 10.1128/mcb.11.2.1156-1160.1991.
2
E2A and E2-2 are subunits of B-cell-specific E2-box DNA-binding proteins.E2A和E2-2是B细胞特异性E2盒DNA结合蛋白的亚基。
Mol Cell Biol. 1993 Jun;13(6):3522-9. doi: 10.1128/mcb.13.6.3522-3529.1993.
3
Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence.异源螺旋-环-螺旋蛋白之间的相互作用产生了能特异性结合共同DNA序列的复合物。
Cell. 1989 Aug 11;58(3):537-44. doi: 10.1016/0092-8674(89)90434-0.
4
Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins.tal-1癌蛋白与E47/E12螺旋-环-螺旋蛋白相关的增强子结合活性。
Mol Cell Biol. 1991 Jun;11(6):3037-42. doi: 10.1128/mcb.11.6.3037-3042.1991.
5
Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains.破坏E47螺旋-环-螺旋蛋白中DNA结合和二聚体形成的突变定位于不同结构域。
Proc Natl Acad Sci U S A. 1990 Jun;87(12):4722-6. doi: 10.1073/pnas.87.12.4722.
6
Helix-loop-helix proteins LYL1 and E2a form heterodimeric complexes with distinctive DNA-binding properties in hematolymphoid cells.螺旋-环-螺旋蛋白LYL1和E2a在血液淋巴样细胞中形成具有独特DNA结合特性的异二聚体复合物。
Mol Cell Biol. 1996 May;16(5):2394-401. doi: 10.1128/MCB.16.5.2394.
7
The E2A and tal-1 helix-loop-helix proteins associate in vivo and are modulated by Id proteins during interleukin 6-induced myeloid differentiation.E2A和tal-1螺旋-环-螺旋蛋白在体内相互作用，并在白细胞介素6诱导的髓系分化过程中受到Id蛋白的调节。
Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):5952-6. doi: 10.1073/pnas.91.13.5952.
8
An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers.E12转录因子的一个抑制结构域可阻止E12同二聚体中的DNA结合，但不能阻止E12异二聚体中的DNA结合。
Cell. 1991 Jan 25;64(2):459-70. doi: 10.1016/0092-8674(91)90653-g.
9
Heterodimers of myogenic helix-loop-helix regulatory factors and E12 bind a complex element governing myogenic induction of the avian cardiac alpha-actin promoter.生肌螺旋-环-螺旋调节因子与E12的异二聚体结合一个控制禽类心脏α-肌动蛋白启动子生肌诱导的复合元件。
Mol Cell Biol. 1991 May;11(5):2439-50. doi: 10.1128/mcb.11.5.2439-2450.1991.
10
Subunit structure of cell-specific E box-binding proteins analyzed by quantitation of electrophoretic mobility shift.
J Biol Chem. 1992 Aug 5;267(22):15642-9.

引用本文的文献

1
Exclusive Characteristics of the p.E555K Dominant-Negative Variant in Autosomal Dominant E47 Deficiency.常染色体显性 E47 缺乏症中 p.E555K 显性负性变异体的独特特征。
J Clin Immunol. 2024 Jul 29;44(7):167. doi: 10.1007/s10875-024-01758-x.
2
Editorial: Molecular switches of the immune system: The E-protein/Id axis in hematopoietic development and function.社论：免疫系统的分子开关：造血发育与功能中的E蛋白/Id轴
Front Immunol. 2022 Nov 4;13:1062734. doi: 10.3389/fimmu.2022.1062734. eCollection 2022.
3
A Screen for Gene Paralogies Delineating Evolutionary Branching Order of Early Metazoa.

本文引用的文献

1
Induction of human malignant T-lymphoblastic cell lines MOLT-3 and jurkat by 12-O-tetradecanoylphorbol-13-acetate: biochemical, physical, and morphological characterization.12-O-十四酰佛波醇-13-乙酸酯对人恶性T淋巴细胞系MOLT-3和Jurkat的诱导作用：生化、物理及形态学特征
J Cell Physiol. 1981 Oct;109(1):181-92. doi: 10.1002/jcp.1041090120.
2
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.从分离的哺乳动物细胞核的可溶性提取物中，RNA聚合酶II进行准确的转录起始。
Nucleic Acids Res. 1983 Mar 11;11(5):1475-89. doi: 10.1093/nar/11.5.1475.
3
Cell-type-specific contacts to immunoglobulin enhancers in nuclei.
用于基因旁系同源物筛选的屏幕，可描绘早期后生动物进化分支顺序。
G3 (Bethesda). 2020 Feb 6;10(2):811-826. doi: 10.1534/g3.119.400951.
4
The Heterodimeric TWIST1-E12 Complex Drives the Oncogenic Potential of TWIST1 in Human Mammary Epithelial Cells.异二聚体TWIST1-E12复合物驱动TWIST1在人乳腺上皮细胞中的致癌潜能。
Neoplasia. 2016 May;18(5):317-327. doi: 10.1016/j.neo.2016.03.007.
5
Dissecting teleost B cell differentiation using transcription factors.利用转录因子解析硬骨鱼 B 细胞分化。
Dev Comp Immunol. 2011 Sep;35(9):898-905. doi: 10.1016/j.dci.2011.01.009. Epub 2011 Jan 17.
6
Transcriptional control of stem cell maintenance in the Drosophila intestine.果蝇肠道干细胞维持的转录控制。
Development. 2010 Mar;137(5):705-14. doi: 10.1242/dev.039404.
7
The genome-wide dynamics of the binding of Ldb1 complexes during erythroid differentiation.基因组范围内 Ldb1 复合物在红细胞分化过程中结合的动态变化。
Genes Dev. 2010 Feb 1;24(3):277-89. doi: 10.1101/gad.551810.
8
Genomic organization and evolution of immunoglobulin kappa gene enhancers and kappa deleting element in mammals.哺乳动物中免疫球蛋白κ基因增强子和κ删除元件的基因组组织与进化
Mol Immunol. 2009 Sep;46(15):3171-7. doi: 10.1016/j.molimm.2009.05.180. Epub 2009 Jun 26.
9
MyoD synergizes with the E-protein HEB beta to induce myogenic differentiation.肌分化决定因子（MyoD）与E蛋白HEBβ协同作用以诱导肌源性分化。
Mol Cell Biol. 2006 Aug;26(15):5771-83. doi: 10.1128/MCB.02404-05.
10
Hyperresponse to T-cell receptor signaling and apoptosis of Id1 transgenic thymocytes.Id1转基因胸腺细胞对T细胞受体信号的高反应性及凋亡
Mol Cell Biol. 2004 Sep;24(17):7313-23. doi: 10.1128/MCB.24.17.7313-7323.2004.
细胞核中与免疫球蛋白增强子的细胞类型特异性接触。
Nature. 1985;313(6005):798-801. doi: 10.1038/313798a0.
4
The Drosophila sex determination gene daughterless has different functions in the germ line versus the soma.果蝇性别决定基因无女儿在生殖系和体细胞中的功能不同。
Cell. 1987 Feb 13;48(3):479-87. doi: 10.1016/0092-8674(87)90198-x.
5
An LFA-3 cDNA encodes a phospholipid-linked membrane protein homologous to its receptor CD2.淋巴细胞功能相关抗原3（LFA-3）的互补脱氧核糖核酸（cDNA）编码一种与其受体CD2同源的磷脂连接膜蛋白。
Nature. 1987;329(6142):840-2. doi: 10.1038/329840a0.
6
The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila.母本性别决定基因无女儿基因具有果蝇外周神经元形成所必需的合子活性。
Genes Dev. 1988 Jul;2(7):843-52. doi: 10.1101/gad.2.7.843.
7
daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex.无女儿基因，一种对果蝇神经发生和性别决定都至关重要的基因，与myc基因和achaete-scute复合体具有序列相似性。
Cell. 1988 Dec 23;55(6):1061-7. doi: 10.1016/0092-8674(88)90250-4.
8
Identification and characterization of two functional domains within the murine heavy-chain enhancer.小鼠重链增强子内两个功能域的鉴定与表征
Mol Cell Biol. 1988 Jan;8(1):145-52. doi: 10.1128/mcb.8.1.145-152.1988.
9
The achaete-scute gene complex of D. melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to myc.黑腹果蝇的无刚毛-小盾片基因复合体：神经发生所需的一组基因中的保守结构域及其与myc的同源性。
Cell. 1987 Jul 31;50(3):415-24. doi: 10.1016/0092-8674(87)90495-8.
10
Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility.免疫球蛋白基因增强子中的蛋白质结合位点决定转录活性和诱导性。
Science. 1987 Jun 19;236(4808):1573-7. doi: 10.1126/science.3109035.