酿酒酵母减数分裂重组过程中形成的特定碱基对错配的修复。
Repair of specific base pair mismatches formed during meiotic recombination in the yeast Saccharomyces cerevisiae.
作者信息
Detloff P, Sieber J, Petes T D
机构信息
Department of Biology, University of North Carolina, Chapel Hill 27599-3280.
出版信息
Mol Cell Biol. 1991 Feb;11(2):737-45. doi: 10.1128/mcb.11.2.737-745.1991.
Abstract
Heteroduplexes formed between DNA strands derived from different homologous chromosomes are an intermediate in meiotic crossing over in the yeast Saccharomyces cerevisiae and other eucaryotes. A heteroduplex formed between wild-type and mutant genes will contain a base pair mismatch; failure to repair this mismatch will lead to postmeiotic segregation (PMS). By analyzing the frequency of PMS for various mutant alleles in the yeast HIS4 gene, we showed that C/C mismatches were inefficiently repaired relative to all other point mismatches. These other mismatches (G/G, G/A, T/T, A/A, T/C, C/A, A/A, and T/G) were repaired with approximately the same efficiency. We found that in spores with unrepaired mismatches in heteroduplexes, the nontranscribed strand of the HIS4 gene was more frequently donated than the transcribed strand. In addition, the direction of repair for certain mismatches was nonrandom.
摘要
源自不同同源染色体的DNA链之间形成的异源双链体是酿酒酵母和其他真核生物减数分裂交叉过程中的一个中间体。野生型基因和突变型基因之间形成的异源双链体将包含一个碱基对错配；未能修复这种错配将导致减数分裂后分离（PMS）。通过分析酵母HIS4基因中各种突变等位基因的PMS频率，我们发现相对于所有其他点错配，C/C错配的修复效率较低。这些其他错配（G/G、G/A、T/T、A/A、T/C、C/A、A/A和T/G）的修复效率大致相同。我们发现，在异源双链体中存在未修复错配的孢子中，HIS4基因的非转录链比转录链更频繁地被传递。此外，某些错配的修复方向是非随机的。
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