Xiao Z J, Chen J, Sun Y, Zheng Z J
Department of Neurology, Second Xiangya Hospital of Central-South University, Changsha, China.
Acta Neurol Belg. 2009 Sep;109(3):205-9.
Serum paraoxonase (PON1) is an HDL-associated esterase that hydrolyzes products of lipid peroxidation and prevents the oxidation of LDL. Paraoxonase 1 (PON1) was implicated in susceptibility to stroke in previous studies. We investigated the correlation between the paraoxonase Gln-Arg 192 polymorphism (PON1Q/R192) and stroke including cerebral hemorrhage and cerebral infarction.
The association between the paraoxonase Gln-Arg 192 polymorphism (PON1Q/R192) and stroke was investigated in 1019 subjects, which involved 305 cases with cerebral hemorrhage, 375 cases with cerebral infarction and 339 healthy controls.
The PON1Q/R192 genotype distribution in the cerebral hemorrhage group was QQ13.1%, QR48.2% and RR38.7% and in the cerebral infarction group was QQ13.6%, QR44.0% and RR42.4% respectively. There was no significant difference in PON1Q/R192 allele and genotype distribution between the patient group and the control group (P > 0.05). The PON1 polymorphism was not associated with cerebral hemorrhage or infarction.
Our study suggests that serum paraoxonase (PON1) is not associated with cerebral hemorrhage or infarction, although it is a lipolactonase which is associated with HDL-apolipoprotein A-I (HDL-apoA-I) and plays a role in the prevention of atherosclerosis.
血清对氧磷酶（PON1）是一种与高密度脂蛋白（HDL）相关的酯酶，可水解脂质过氧化产物并防止低密度脂蛋白（LDL）氧化。先前的研究表明对氧磷酶1（PON1）与中风易感性有关。我们研究了对氧磷酶Gln-Arg 192多态性（PON1Q/R192）与包括脑出血和脑梗死在内的中风之间的相关性。
在1019名受试者中研究了对氧磷酶Gln-Arg 192多态性（PON1Q/R192）与中风之间的关联，其中包括305例脑出血患者、375例脑梗死患者和339名健康对照者。
脑出血组中PON1Q/R192基因型分布为QQ型占13.1%，QR型占48.2%，RR型占38.7%；脑梗死组中QQ型占13.6%，QR型占44.0%，RR型占42.4%。患者组与对照组之间的PON1Q/R192等位基因和基因型分布无显著差异（P>0.05）。PON1多态性与脑出血或梗死无关。
我们的研究表明，血清对氧磷酶（PON1）虽然是一种与HDL-载脂蛋白A-I（HDL-apoA-I）相关并在预防动脉粥样硬化中起作用的脂内酯酶，但与脑出血或梗死无关。
