对氧磷酶1（PON1）与中风；基因变异的困境。
Paraoxonase 1 (PON1) and stroke; the dilemma of genetic variation.
作者信息
Tajbakhsh Amir, Rezaee Mehdi, Rivandi Mahdi, Forouzanfar Faranak, Afzaljavan Fahimeh, Pasdar Alireza
机构信息
Department of Modern Sciences & Technologies, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran;; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR, Iran.
Department of Medical Biotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR, Iran.
出版信息
Clin Biochem. 2017 Dec;50(18):1298-1305. doi: 10.1016/j.clinbiochem.2017.08.001. Epub 2017 Aug 3.
Ischaemic stroke, which is mostly caused by atherosclerosis, is one of the most widely causes of mortality and morbidity. One of the most important enzymatic activities of paraoxonase-1 (PON1) in association with high-density lipoprotein (HDL) is the prevention of low-density lipoprotein (LDL) oxidation, which gives it an anti-atherogenic activity. PON1 expression and activity is influenced by various factors; the most important of which is genetic polymorphism, mainly single nucleotide polymorphisms (SNPs). The results of various studies in different populations indicate that some SNPs of the PON1 gene are associated with stroke. Therefore, in this review we studied various researches, in which the association of PON1 SNPs with stroke had been investigated in different populations.
缺血性中风主要由动脉粥样硬化引起，是导致死亡和发病的最常见原因之一。对氧磷酶-1（PON1）与高密度脂蛋白（HDL）相关的最重要酶活性之一是防止低密度脂蛋白（LDL）氧化，这赋予其抗动脉粥样硬化活性。PON1的表达和活性受多种因素影响；其中最重要的是基因多态性，主要是单核苷酸多态性（SNP）。不同人群的各种研究结果表明，PON1基因的某些SNP与中风有关。因此，在本综述中，我们研究了各种研究，其中在不同人群中调查了PON1 SNP与中风的关联。
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