Sönmez K, Bahar B, Karabulut R, Gülbahar O, Poyraz A, Türkyilmaz Z, Sancak B, Başaklar A C
Department of Paediatric Surgery, Gazi University, Faculty of Medicine, Ankara, Turkey.
B-ENT. 2009;5(3):149-52.
In this study we aimed to investigate the effects of different suture materials on wound healing and infection in subcutaneous closure techniques.
Twenty-nine rats were randomly allocated to 5 groups. All subjects received 2-cm vertical dermal and subdermal incisions on their backs under sterile and proper surgical conditions. The subdermal cuts were then closed with vicryl (polyglycolic acid), biosyn (monofilament glycomer), prolene (polypropylene) and tissue adhesive (2-octylcyanoacrylate). After 10 days, all sutured areas were examined for seroma, haematoma formation and cosmetic outcome. The incisional lines were excised with 1-cm-wide skin strips and tissue hydroxyproline levels were determined. The specimens obtained were evaluated for the presence of giant cells, mononuclear cells, fibrosis and neutrophils.
No differences in tissue hydroxyproline levels were found between any of the suture materials used. Fibrotic process and inflammatory cell infiltration were more prominent in the biosyn and prolene groups than in other groups. Foreign body giant cells were observed in the biosyn group.
Vicryl and tissue adhesive should be preferred in subcutaneous closure techniques.
在本研究中，我们旨在调查不同缝合材料对皮下闭合技术中伤口愈合和感染的影响。
将29只大鼠随机分为5组。所有实验对象在无菌且适当的手术条件下，于背部进行2厘米长的垂直真皮及皮下切口。然后分别用薇乔（聚乙醇酸）、生物合成线（单丝聚糖醇）、普理灵（聚丙烯）和组织粘合剂（2-氰基丙烯酸辛酯）闭合皮下切口。10天后，检查所有缝合区域是否有血清肿、血肿形成及外观效果。用1厘米宽的皮肤条带切除切口线，并测定组织羟脯氨酸水平。对获取的标本进行巨细胞、单核细胞、纤维化和中性粒细胞检查。
所使用的任何缝合材料之间，组织羟脯氨酸水平均未发现差异。生物合成线组和普理灵组的纤维化过程和炎性细胞浸润比其他组更显著。在生物合成线组观察到异物巨细胞。
在皮下闭合技术中，应优先选择薇乔和组织粘合剂。
