Souza Sandro Cilindro de, Oliveira Washington Luiz de, Soares Dario Fernando de Oliveira Santos, Briglia Carlos Henrique, Athanázio Paulo Roberto, Cerqueira Martins Dias de, Guimarães Pedro Hamilton, Carreiro Mário Castro
Adventist Education Institute, Capoeiruçu, Bahia, Brazil.
Acta Cir Bras. 2007 Jul-Aug;22(4):309-16. doi: 10.1590/s0102-86502007000400013.
To compare the biocompatibility of ethyl-cyanoacrylate (ECA) and octylcyanoacrylate (OCA) wound closures to sutures in rat skin.
Twenty-four male Wistar rats were subjected to three incisions which were closed using ECA, OCA or sutures . Rats were divided into four groups which received biopsies on the 3rd, 7th, 14th or 21st post-operative days. Necrosis, inflammation, dermatitis, infection, dehiscence, cicatricial enlargement and costs were examined; the histopathology evaluated was epithelialization, deep openings, foreign substance reaction, residues of synthesis material, fibrosis, inflammation, dehiscence and necrosis.
The tissue adhesives presented the largest dehiscence levels, and ECA the lowest cost while the other measures were similar. Regarding histopathology, deep openings were more common with OCA and granulomas were most frequently obtained with ECA. The two tissue adhesives produces less inflammation than the inicial suture from post-operative day 7, while ECA and OCA cause similar inflammatory reactions. ECA did not differ significantly from OCA and sutures on other measures.
ECA was well tolerated in this study and did not induce necrosis, allergic reactions or infections, presenting several advantages in relation to OCA and sutures, including lower costs and fewer complications.
比较大鼠皮肤中氰基丙烯酸乙酯（ECA）和氰基丙烯酸辛酯（OCA）伤口闭合材料与缝线的生物相容性。
对24只雄性Wistar大鼠进行三处切口，分别使用ECA、OCA或缝线进行闭合。将大鼠分为四组，分别在术后第3、7、14或21天进行活检。检查坏死、炎症、皮炎、感染、裂开、瘢痕增大及费用情况；评估的组织病理学指标包括上皮化、深部开口、异物反应、合成材料残留、纤维化、炎症、裂开和坏死。
组织粘合剂的裂开程度最大，ECA费用最低，其他指标相似。在组织病理学方面，OCA导致的深部开口更常见，ECA导致的肉芽肿最常见。从术后第7天起，两种组织粘合剂引起的炎症比初始缝线少，而ECA和OCA引起的炎症反应相似。在其他指标上，ECA与OCA和缝线无显著差异。
在本研究中，ECA耐受性良好，未引起坏死、过敏反应或感染，与OCA和缝线相比具有若干优势，包括成本更低和并发症更少。
