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基层医疗中呼吸道感染快速诊断检测的使用及抗生素选择——一项6年随访研究

Use of rapid diagnostic tests and choice of antibiotics in respiratory tract infections in primary healthcare--a 6-y follow-up study.

作者信息

Neumark Thomas, Brudin Lars, Mölstad Sigvard

机构信息

Lindsdals Primary Health Centre, Förlösavägen 4, Kalmar, Sweden.

出版信息

Scand J Infect Dis. 2010;42(2):90-6. doi: 10.3109/00365540903352932.

Abstract

The aim of this retrospective study of electronic patient records in primary health care in Kalmar County, Sweden, was to describe consultations for respiratory tract infections (RTIs) in relation to age, choice of antibiotics and the use of rapid diagnostic tests. During the period 1999-2005, 240,445 visits for RTI were recorded. Children aged <2 y and especially those aged 2-16 y with acute otitis media (AOM), showed decreasing consultations between 2000 and 2005. The consultations for sore throat declined during the study period in all age groups and in 65% of these, antibiotics were prescribed, primarily penicillin V (82%). In sore throat, a positive Strep-A test result was followed by antibiotic prescription in about 92% of cases; when negative, the antibiotic prescription rate was 40%. C-reactive protein (CRP) was analyzed in 36% of all consultations for RTI. In common cold and acute bronchitis, the prescription rates of antibiotics rose with rising CRP. The results show that near-patient tests were used extensively, but often not in accordance with the guidelines. Antibiotic use decreased mainly as a consequence of declined visiting frequencies. This indicates that the new guidelines for AOM and sore throat may have influenced patient consultation habits more than physician prescribing habits.

摘要

这项针对瑞典卡尔马郡初级卫生保健中电子病历的回顾性研究旨在描述与年龄、抗生素选择以及快速诊断检测使用相关的呼吸道感染(RTIs)诊疗情况。在1999年至2005年期间,共记录了240445次呼吸道感染就诊病例。2岁以下儿童,尤其是患有急性中耳炎(AOM)的2至16岁儿童,在2000年至2005年间就诊次数呈下降趋势。在研究期间,所有年龄组的咽痛就诊次数均有所下降,其中65%的病例开具了抗生素,主要是青霉素V(82%)。在咽痛病例中,A组链球菌检测结果呈阳性时,约92%的病例随后会开具抗生素;检测结果为阴性时,抗生素开具率为40%。在所有呼吸道感染诊疗病例中,36%的病例进行了C反应蛋白(CRP)分析。在普通感冒和急性支气管炎病例中,抗生素开具率随CRP升高而上升。结果表明,即时检验被广泛使用,但往往不符合指南要求。抗生素使用量下降主要是就诊频率降低所致。这表明,关于急性中耳炎和咽痛的新指南对患者就诊习惯的影响可能大于对医生开药习惯的影响。

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