Cambridge Centre for Brain Repair, Cambridge, CB2 0PY, UK.
Regen Med. 2009 Nov;4(6):855-64. doi: 10.2217/rme.09.59.
Retinal degenerative diseases are the leading cause of incurable blindness worldwide. Furthermore, existing pharmacological and surgical interventions are only partially effective in halting disease progression, thus adjunctive neuroprotective strategies are desperately needed to preserve vision. Stem cells appear to possess inherent neuroprotective abilities, at least in part by providing neurotrophic support to injured neurons. Advances in stem cell biology offer the hope of new therapies for a broad range of neurodegenerative conditions, including those of the retina. Experimental cell-mediated therapies also hint at the tantalizing possibility of achieving retinal neuronal replacement and regeneration, once cells are lost to the disease process. This article summarizes the latest advances in cell therapies for neuroprotection and regeneration in neurodegenerative pathologies of both the inner and outer retina.
视网膜退行性疾病是全球范围内导致不可治愈失明的主要原因。此外，现有的药理学和手术干预措施仅能部分有效阻止疾病进展，因此迫切需要辅助神经保护策略来保护视力。干细胞似乎具有内在的神经保护能力，至少部分原因是为受损神经元提供神经营养支持。干细胞生物学的进步为包括视网膜在内的多种神经退行性疾病的新疗法带来了希望。实验性细胞介导的治疗方法也暗示了一旦细胞因疾病过程而丢失，实现视网膜神经元替代和再生的诱人可能性。本文总结了细胞疗法在治疗内、外视网膜神经退行性病变中的神经保护和再生方面的最新进展。
