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干细胞在眼部神经退行性变中的新兴作用:炒作还是希望?

The emerging role of stem cells in ocular neurodegeneration: hype or hope?

机构信息

Department of Neurology, Postgraduate Institute of Medical Education and Research, Sector-12, Chandigarh 160012, India.

出版信息

Mol Cell Biochem. 2012 Jun;365(1-2):65-76. doi: 10.1007/s11010-012-1244-8.

DOI:10.1007/s11010-012-1244-8
PMID:22290231
Abstract

Affecting over a hundred million individuals worldwide, retinal diseases are among the leading causes of irreversible visual impairment and blindness. Thus, an appropriate study models, especially animal models, are essential to furthering our understanding of the etiology, pathology, and progression of these diseases. In this review, we provide an overview of retinal disorders in the context of biotherapeutic approaches in these disorders.

摘要

影响全球超过一亿人,视网膜疾病是导致不可逆性视力损害和失明的主要原因之一。因此,适当的研究模型,特别是动物模型,对于深入了解这些疾病的病因、病理和进展至关重要。在这篇综述中,我们提供了在这些疾病的生物治疗方法的背景下对视网膜疾病的概述。

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The emerging role of stem cells in ocular neurodegeneration: hype or hope?干细胞在眼部神经退行性变中的新兴作用:炒作还是希望?
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[Advancement in the study of embryonic stem cells and the emerging potential promising future of ocular tissue engineering].[胚胎干细胞研究进展与眼组织工程的新兴潜在前景]
Yan Ke Xue Bao. 2000 Jun;16(2):118-23.
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Current approaches and future prospects for stem cell rescue and regeneration of the retina and optic nerve.当前用于干细胞挽救和视网膜及视神经再生的方法及未来展望。
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Using stem cells to mend the retina in ocular disease.利用干细胞修复眼部疾病的视网膜。
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Stem Cell-Based Regeneration and Restoration for Retinal Ganglion Cell: Recent Advancements and Current Challenges.基于干细胞的视网膜神经节细胞再生和修复:最新进展和当前挑战。
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Stem Cell Rev Rep. 2017 Oct;13(5):598-602. doi: 10.1007/s12015-017-9750-4.
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Anat Cell Biol. 2022 Jun 30;55(2):217-228. doi: 10.5115/acb.22.006.
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Brain-Derived Neurotrophic Factor in children with Autism Spectrum Disorder.自闭症谱系障碍儿童中的脑源性神经营养因子
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Bone marrow mesenchymal stem cells protect against retinal ganglion cell loss in aged rats with glaucoma.

本文引用的文献

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Pathophysiology of stroke and stroke-induced retinal ischemia: emerging role of stem cells.中风和中风引起的视网膜缺血的病理生理学:干细胞的新作用。
J Cell Physiol. 2012 Mar;227(3):1269-79. doi: 10.1002/jcp.23048.
2
Emergence of chondrogenic progenitor stem cells in transplantation biology-prospects and drawbacks.移植生物学中软骨祖细胞的出现——前景与挑战。
J Cell Biochem. 2012 Feb;113(2):397-403. doi: 10.1002/jcb.23367.
3
Diffusion tensor imaging detects retinal ganglion cell axon damage in the mouse model of optic nerve crush.
骨髓间充质干细胞可防止老年青光眼大鼠的视网膜神经节细胞丢失。
Clin Interv Aging. 2013;8:1467-70. doi: 10.2147/CIA.S47350. Epub 2013 Oct 31.
弥散张量成像检测视神经挤压模型中小鼠视网膜神经节细胞轴突损伤。
Invest Ophthalmol Vis Sci. 2011 Sep 1;52(9):7001-6. doi: 10.1167/iovs.11-7619.
4
Recruitment of stem cells into the injured retina after laser injury.激光损伤后干细胞向受损视网膜的募集。
Stem Cells Dev. 2012 Feb 10;21(3):448-54. doi: 10.1089/scd.2011.0002. Epub 2011 Jul 28.
5
Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice.成体鼠诱导多能干细胞源性光感受器前体细胞移植恢复退行性变小鼠的视网膜结构和功能。
PLoS One. 2011 Apr 29;6(4):e18992. doi: 10.1371/journal.pone.0018992.
6
Effect of brimonidine on retinal and choroidal neovascularization in a mouse model of retinopathy of prematurity and laser-treated rats.溴莫尼定对早产儿视网膜病变模型小鼠和激光处理大鼠的视网膜和脉络膜新生血管的影响。
Invest Ophthalmol Vis Sci. 2011 Jul 20;52(8):5424-31. doi: 10.1167/iovs.10-6262.
7
Human induced pluripotent stem-derived retinal pigment epithelium (RPE) cells exhibit ion transport, membrane potential, polarized vascular endothelial growth factor secretion, and gene expression pattern similar to native RPE.人诱导多能干细胞衍生的视网膜色素上皮 (RPE) 细胞表现出类似天然 RPE 的离子转运、膜电位、极化血管内皮生长因子分泌和基因表达模式。
Stem Cells. 2011 May;29(5):825-35. doi: 10.1002/stem.635.
8
Validation of structural and functional lesions of diabetic retinopathy in mice.小鼠糖尿病视网膜病变结构和功能损伤的验证
Mol Vis. 2010 Oct 19;16:2121-31.
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Human adult bone marrow-derived somatic cells rescue vision in a rodent model of retinal degeneration.人成年骨髓来源的体细胞在视网膜变性的啮齿动物模型中挽救视力。
Exp Eye Res. 2010 Sep;91(3):449-55. doi: 10.1016/j.exer.2010.06.024. Epub 2010 Jul 13.
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Adult ciliary epithelial cells, previously identified as retinal stem cells with potential for retinal repair, fail to differentiate into new rod photoreceptors.成体纤毛上皮细胞,曾被鉴定为具有视网膜修复潜力的视网膜干细胞,未能分化为新的杆状光感受器。
Stem Cells. 2010 Jun;28(6):1048-59. doi: 10.1002/stem.423.