Department of Biochemistry and Molecular Biology, University of Ferrara, Ferrara, Italy.
Gynecol Endocrinol. 2009 Jun;25(6):413-7. doi: 10.1080/09513590902770123.
To investigate the role of menopause, body mass index (BMI) and aging on body fat distribution in women.
In this population-based cross-sectional study, 335 women (126 in pre-menopause, 75 in peri-menopause and 134 in post-menopause according to Stages of Reproductive Aging Workshop criteria) were evaluated for body mass composition and fat distribution by dual X-ray absorptiometry procedure. A sub-group of 79 women with similar age and BMI was extracted from the sample to examine the relative influence of BMI in body fat distribution.
ANCOVA analysis of total sample showed an age-independent increase of total fat mass (p < 0.001) and percentage on total weight (p < 0.001), arms fat mass (p < 0.01), legs fat mass percentage on total fat (p < 0.05) and trunk fat mass (p < 0.001) and percentage (p < 0.05) in peri- and post- with respect to pre-menopausal women. In the sub-sample including age and BMI matched women the difference of regional fat parameters among menopausal status was no more statistically significant.
BMI, and not age, is the main determinant of the increase of body fat mass (total and abdominal) observed during the menopausal transition.
探讨绝经、体重指数（BMI）和衰老对女性体脂分布的影响。
在这项基于人群的横断面研究中，通过双能 X 线吸收仪程序评估了 335 名女性（根据生殖衰老研讨会标准，126 名处于绝经前期，75 名处于围绝经期，134 名处于绝经后期）的体重组成和脂肪分布。从样本中提取了一个年龄和 BMI 相似的亚组，以检查 BMI 对体脂分布的相对影响。
总样本的方差分析显示，总脂肪量（p < 0.001）和总体重百分比（p < 0.001）、手臂脂肪量（p < 0.01）、腿部脂肪量占总脂肪百分比（p < 0.05）和躯干脂肪量（p < 0.001）和百分比（p < 0.05）在围绝经期和绝经后期与绝经前期女性相比呈独立于年龄的增加。在包括年龄和 BMI 匹配女性的亚组中，绝经状态之间的区域脂肪参数差异不再具有统计学意义。
在绝经过渡期间观察到的体脂肪量（总体和腹部）的增加，主要由 BMI 而不是年龄决定。
