Department of Experimental Pathology, Cancer Research Section, University of Bologna, Bologna, Italy.
Future Oncol. 2009 Nov;5(9):1449-75. doi: 10.2217/fon.09.97.
Rhabdomyosarcoma is a group of soft-tissue sarcomas that share features of skeletal myogenesis, but show extensive heterogeneity in histology, age and site of onset, and prognosis. This review matches recent molecular data with biological features of rhabdomyosarcoma. Alterations in molecular pathways, animal models, cell of origin and potential new therapeutic targets are discussed.
横纹肌肉瘤是一组软组织肉瘤，具有骨骼肌发生的特征，但在组织学、发病年龄和部位以及预后方面存在广泛的异质性。本综述将最新的分子数据与横纹肌肉瘤的生物学特征相匹配。讨论了分子途径、动物模型、起源细胞和潜在新治疗靶点的改变。
