Department of Clinical Pathology, Faculty of Medicine, Mansoura University, El Gomhoria Street 60, 35516 Mansoura, Egypt.
Microbiol Immunol. 2009 Nov;53(11):603-8. doi: 10.1111/j.1348-0421.2009.00162.x.
There is a deficiency in the data concerning the role of hMPV in lower respiratory tract infections in adults, and until now there has been no data available regarding the prevalence of hMPV in adults in our region. In the present study the association of hMPV with varieties of lower respiratory tract disorders in immunocompetent adult patients, either alone or with bacterial pathogens, has been highlighted. Eighty-eight patients were included in the study. They included 46 males and 42 females with an age range of 38-65 years. Patients presented with lower respiratory tract infections associated with acute exacerbation of asthma (67%), pneumonia (17%), and acute exacerbation of chronic obstructive lung diseases. Sputum and nasopharyngeal samples were obtained from the patients and subjected to a full microbiological study. In addition, detection of hMPV was performed by nested reverse transcriptase polymerase chain reaction. The pathogens isolated were Streptococcus pneumoniae 46.6%, Staphylococci aureus 35.2%, and human metapneumovirus 13.6%. Influenza virus and rhinovirus were each isolated from 4.5% of patients. Human metapneumovirus was associated with S. pneumoniae in 4.5% in studied patients, while in 9.1% it was the only pathogen found in those patients. The commonest clinical condition with significant association with human metapneumovirus was pneumonia. The clinical and laboratory studies demonstrated an association between lower respiratory tract infections in adults and hMPV either as sole pathogen or in association with Streptococcus pneumoniae. It was a common pathogen in community-acquired pneumonia.
有关 hMPV 在成人下呼吸道感染中的作用的数据存在不足，迄今为止，我们地区还没有关于成人 hMPV 患病率的数据。在本研究中，强调了 hMPV 与免疫功能正常的成年患者下呼吸道疾病的各种变异有关，无论是单独存在还是与细菌病原体有关。研究纳入了 88 例患者。其中包括 46 名男性和 42 名女性，年龄在 38-65 岁之间。患者出现下呼吸道感染，伴有哮喘急性加重（67%）、肺炎（17%）和慢性阻塞性肺疾病急性加重。从患者中获得痰和鼻咽样本，并进行全面的微生物学研究。此外，通过巢式逆转录聚合酶链反应检测 hMPV。分离出的病原体为肺炎链球菌 46.6%、金黄色葡萄球菌 35.2%和人类偏肺病毒 13.6%。流感病毒和鼻病毒分别从 4.5%的患者中分离出来。人类偏肺病毒与研究患者中的肺炎链球菌有关，占 4.5%，而在 9.1%的患者中，它是唯一发现的病原体。与人类偏肺病毒最常见的临床状况是肺炎，具有显著相关性。临床和实验室研究表明，成人下呼吸道感染与 hMPV 无论是作为单一病原体还是与肺炎链球菌有关。它是社区获得性肺炎的常见病原体。
