Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India.
J Pharm Pharmacol. 2009 Nov;61(11):1529-36. doi: 10.1211/jpp/61.11.0013.
Myocardial fibrosis and oxidative stress accompany a number of cardiac disorders such as hypertrophic cardiomyopathy, hypertensive heart disease and cardiac failure. Stem bark of Terminalia arjuna has been advocated for cardiac ailments. The present study evaluated the effects of T. arjuna bark extract on myocardial fibrosis and oxidative stress induced by chronic beta-adrenoceptor stimulation.
Aqueous extract of T. arjuna bark was evaluated at 63, 125 and 250 mg/kg given orally for antifibrotic and antioxidant effects in rats given the selective beta-adrenoceptor agonist isoprenaline (5 mg/kg s.c.) for 28 days. Captopril (50 mg/kg per day, given orally), an inhibitor of angiotensin-converting enzyme used as a standard cardioprotective drug, was used as a positive control.
Isoprenaline caused fibrosis, increased oxidative stress and cardiac hypertrophy (increased heart weight : body weight ratio and cardiomyocyte diameter). The T. arjuna bark extract and captopril significantly prevented the isoprenaline-induced increase in oxidative stress and decline in endogenous antioxidant level. Both also prevented fibrosis but not the increase in heart weight : body weight ratio.
T. arjuna protects against myocardial changes induced by chronic beta-adrenoceptor stimulation.
心肌纤维化和氧化应激伴随着多种心脏疾病，如肥厚型心肌病、高血压性心脏病和心力衰竭。诃子的树皮已被用于心脏疾病的治疗。本研究评估了诃子树皮提取物对慢性β-肾上腺素能受体刺激引起的心肌纤维化和氧化应激的影响。
以水提诃子树皮提取物，每天口服 63、125 和 250mg/kg，用于评价其在 28 天内皮下给予选择性β-肾上腺素能受体激动剂异丙肾上腺素（5mg/kg）的大鼠中的抗纤维化和抗氧化作用。血管紧张素转换酶抑制剂卡托普利（每天 50mg/kg，口服）用作标准的心脏保护药物作为阳性对照。
异丙肾上腺素引起纤维化、氧化应激增加和心肌肥大（心脏重量：体重比和心肌细胞直径增加）。诃子树皮提取物和卡托普利可显著预防异丙肾上腺素引起的氧化应激增加和内源性抗氧化水平下降。两者还可预防纤维化，但不能预防心脏重量：体重比增加。
诃子可预防慢性β-肾上腺素能受体刺激引起的心肌变化。
