Epidemiology Program, Cancer Research Center of Hawaii, University of Hawaii, 1236 Lauhala Street, Honolulu, Hawaii 96813, USA.
Endocr Relat Cancer. 2010 Feb 18;17(1):125-34. doi: 10.1677/ERC-09-0211. Print 2010 Mar.
To add to the existing evidence that comes mostly from White populations, we conducted a nested case-control study to examine the association between sex hormones and breast cancer risk within the Multiethnic Cohort that includes Japanese American, White, Native Hawaiian, African American, and Latina women. Of the postmenopausal women for whom we had a plasma sample, 132 developed breast cancer during follow-up. Two controls per case, matched on study area (Hawaii, Los Angeles), ethnicity/race, birth year, date and time of blood draw and time fasting, were randomly selected from the women who had not developed breast cancer. Levels of estradiol (E(2)), estrone (E(1)), androstenedione, dehydroepiandrosterone (DHEA), and testosterone were quantified by RIA after organic extraction and Celite column partition chromatography. E(1) sulfate, DHEA sulfate (DHEAS), and sex hormone-binding globulin (SHBG) were quantified by direct immunoassays. Based on conditional logistic regression, the sex hormones were positively associated and SHBG was negatively associated with breast cancer risk. All associations, except those with DHEAS and testosterone showed a significant linear trend. The odds ratio (OR) associated with a doubling of E(2) levels was 2.26 (95% confidence interval (CI) 1.58-3.25), and the OR associated with a doubling of testosterone levels was 1.34 (95% CI 0.98-1.82). The associations in Japanese American women, who constituted 54% of our sample, were similar to or nonsignificantly stronger than in the overall group. This study provides the best evidence to date that the association between sex hormones and breast cancer risk is generalizable to an ethnically diverse population.
为了增加现有的主要来自白人群体的证据，我们进行了一项巢式病例对照研究，以检查多民族队列中激素与乳腺癌风险之间的关系，该队列包括日裔美国人、白种人、夏威夷原住民、非裔美国人和拉丁裔女性。在我们有血浆样本的绝经后女性中，有 132 人在随访期间患上了乳腺癌。从没有患乳腺癌的女性中，按研究区域（夏威夷、洛杉矶）、族裔/种族、出生年份、采血日期和时间以及禁食时间，随机选择每例病例的 2 名对照。通过有机提取和 Celite 柱分相色谱法对雌二醇 (E(2))、雌酮 (E(1))、雄烯二酮、脱氢表雄酮 (DHEA) 和睾酮进行 RIA 定量。通过直接免疫测定法对 E(1)硫酸盐、DHEA 硫酸盐 (DHEAS) 和性激素结合球蛋白 (SHBG) 进行定量。基于条件逻辑回归，这些激素与乳腺癌风险呈正相关，SHBG 呈负相关。除了与 DHEAS 和睾酮的关联外，所有关联均显示出显著的线性趋势。E(2)水平翻倍相关的比值比 (OR) 为 2.26（95%置信区间 (CI) 1.58-3.25），而睾酮水平翻倍相关的 OR 为 1.34（95% CI 0.98-1.82）。在占我们样本 54%的日裔美国女性中，这些关联与总体组相似或略强。这项研究提供了迄今为止最好的证据，表明激素与乳腺癌风险之间的关联可推广到种族多样化的人群。
