Stone Sophia A, Han Claire J, Senn Taurence, Korde Larissa A, Allott Kristen, Reding Scott, Whittington Dale, Reding Kerryn W
University of Washington, Seattle, WA, USA.
Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
West J Nurs Res. 2019 Nov;41(11):1602-1622. doi: 10.1177/0193945918820672. Epub 2019 Jan 7.
Sedentary lifestyles and obesity are known risk factors for breast cancer. Elevated estrogen levels correlate with obesity and, independently, with increased breast cancer risk. Lifestyle interventions that reduce obesity may mitigate this risk, potentially via estrogen pathways. In a 6-month lifestyle intervention, overweight/obese women with high breast cancer risk were randomized to control ( = 7) or intervention ( = 6) and analyzed for sex hormone levels. Serum and urine hormones were evaluated by ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and sex hormone binding globulin (SHBG) by enzyme-linked immunosorbent assay (ELISA). Serum estrone (E1) and estradiol (E2) were reduced by 12.1% and 50.8%, respectively, at 9 months in the intervention group, which differed from controls ( = .043 and .020). This contrasted with a 73.3% increase in urine E1 at 6 months in the intervention group ( = .035). These results suggest that a lifestyle intervention led to a favorable estrogen profile in relation to breast cancer risk.
久坐不动的生活方式和肥胖是已知的乳腺癌风险因素。雌激素水平升高与肥胖相关，且独立地与乳腺癌风险增加相关。减少肥胖的生活方式干预可能会降低这种风险，可能是通过雌激素途径。在一项为期6个月的生活方式干预中，将具有高乳腺癌风险的超重/肥胖女性随机分为对照组（n = 7）或干预组（n = 6），并分析其性激素水平。血清和尿液激素通过超高效液相色谱-串联质谱法（UPLC-MS/MS）进行评估，性激素结合球蛋白（SHBG）通过酶联免疫吸附测定法（ELISA）进行评估。干预组在9个月时血清雌酮（E1）和雌二醇（E2）分别降低了12.1%和50.8%，这与对照组不同（P = 0.043和0.020）。这与干预组在6个月时尿液E1增加73.3%形成对比（P = 0.035）。这些结果表明，生活方式干预导致了与乳腺癌风险相关的有利雌激素谱。
