Kim Yeonju, Franke Adrian A, Shvetsov Yurii B, Wilkens Lynne R, Cooney Robert V, Lurie Galina, Maskarinec Gertraud, Hernandez Brenda Y, Le Marchand Loïc, Henderson Brian E, Kolonel Laurence N, Goodman Marc T
Cancer Epidemiology Program, University of Hawaii Cancer Center, 701 Ilalo Street, Honolulu, HI 96813, USA.
BMC Cancer. 2014 Jan 17;14:29. doi: 10.1186/1471-2407-14-29.
Higher sunlight exposure is correlated with lower incidence of breast cancer in ecological studies, but findings from prospective studies regarding the association of circulating levels of vitamin D with the risk of breast cancer have been null. The objective of this study was to examine the relation between plasma levels of vitamin D and the risk of postmenopausal breast cancer.
We conducted a nested case-control study within the Multiethnic Cohort Study of five race/ethnic groups (white, African-American, Native Hawaiian, Japanese, and Latino) from Hawaii and Los Angeles between 2001 and 2006. Pre-diagnostic plasma levels of 25-hydroxyvitamin D2 [25(OH)D2], 25-hydroxyvitamin D3 [25(OH)D3] and 25(OH)D (sum of 25(OH)D2 and 25(OH)D3) were examined among 707 postmenopausal breast cancer cases and matched controls.
Using conditional logistic regression models, 20 ng/mL increases of plasma 25(OH)D3 (odds ratio (OR) 0.28; 95% confidence interval (CI) 0.14-0.56) and 25(OH)D (OR 0.43; 95% CI 0.23-0.80) were inversely associated with breast cancer risk among white women, but not among women in other race/ethnic groups. Using two-segmented, piecewise-linear logistic regression models, the change-points of the ORs, either for 25(OH)D3 or for 25(OH)D, were detected as 20 ng/mL among whites.
Circulating 25(OH)D3 and 25(OH)D were associated with a reduced risk of postmenopausal breast cancer among whites, but not in other ethnic groups, who reside in low latitude regions.
在生态学研究中，较高的阳光暴露与较低的乳腺癌发病率相关，但前瞻性研究关于循环维生素D水平与乳腺癌风险之间关联的结果尚无定论。本研究的目的是探讨血浆维生素D水平与绝经后乳腺癌风险之间的关系。
我们在2001年至2006年期间于夏威夷和洛杉矶开展的多民族队列研究中进行了一项巢式病例对照研究，该研究涉及五个种族/族裔群体（白人、非裔美国人、夏威夷原住民、日本人和拉丁裔）。在707例绝经后乳腺癌病例及其匹配对照中检测了诊断前血浆25-羟基维生素D2 [25(OH)D2]、25-羟基维生素D3 [25(OH)D3] 和25(OH)D（25(OH)D2与25(OH)D3之和）的水平。
使用条件逻辑回归模型，血浆25(OH)D3升高20 ng/mL（比值比（OR）0.28；95%置信区间（CI）0.14 - 0.56）和25(OH)D升高20 ng/mL（OR 0.43；95% CI 0.23 - 0.80）与白人女性患乳腺癌的风险呈负相关，但在其他种族/族裔群体的女性中并非如此。使用两段式、分段线性逻辑回归模型，在白人中，25(OH)D3或25(OH)D的OR变化点均检测为20 ng/mL。
循环中的25(OH)D3和25(OH)D与居住在低纬度地区的白人绝经后乳腺癌风险降低相关，但在其他种族群体中并非如此。
