Munich Center of Integrated Protein Science (CIPSM), Ludwig-Maximilians-Universität München, Mikrobiologie, 82152 Martinsried, Germany.
Sci Signal. 2009 Nov 10;2(96):pe71. doi: 10.1126/scisignal.296pe71.
Histidine protein kinases and serine, threonine, or tyrosine protein kinases play essential roles in signal transduction in prokaryotes and eukaryotes. A third type of protein kinase, an arginine protein kinase, has been identified. McsB of Bacillus subtilis phosphorylates the heat shock transcriptional regulator CtsR and can be regarded as the founding member of arginine protein kinases.
组氨酸蛋白激酶、丝氨酸/苏氨酸蛋白激酶和酪氨酸蛋白激酶在原核生物和真核生物的信号转导中发挥着重要作用。第三种蛋白激酶——精氨酸蛋白激酶也已经被鉴定出来。枯草芽孢杆菌的 McsB 可使热休克转录调控因子 CtsR 发生磷酸化，它可以被视为精氨酸蛋白激酶的创始成员。
