了解神经退行性变中的微小RNA。
Understanding microRNAs in neurodegeneration.
作者信息
Eacker Stephen M, Dawson Ted M, Dawson Valina L
机构信息
Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
出版信息
Nat Rev Neurosci. 2009 Dec;10(12):837-41. doi: 10.1038/nrn2726. Epub 2009 Nov 11.
Abstract
Interest in the functions of microRNAs (miRNAs) in the nervous system has recently expanded to include their roles in neurodegeneration. Investigations have begun to reveal the influence of miRNAs on both neuronal survival and the accumulation of toxic proteins that are associated with neurodegeneration, and are providing clues as to how these toxic proteins can influence miRNA expression.
摘要
最近，对微小RNA（miRNA）在神经系统中功能的关注范围已扩大到包括它们在神经退行性变中的作用。研究已开始揭示miRNA对神经元存活以及与神经退行性变相关的毒性蛋白积累的影响，并正在提供关于这些毒性蛋白如何影响miRNA表达的线索。
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