DNA 纳米结构的酶切抗性增强。
Enhanced resistance of DNA nanostructures to enzymatic digestion.
机构信息
Department of Chemical Engineering, University of Massachusetts, Amherst, MA, USA.
出版信息
Chem Commun (Camb). 2009 Dec 7(45):7036-8. doi: 10.1039/b917661f. Epub 2009 Oct 13.
DOI:10.1039/b917661f
PMID:19904386
Abstract
The ability of nucleases to perform their catalytic functions depends on the sequence and structural features of target DNA substrates. Due to their size and shape, several DNA tetrahedra are resistant to the action of specific and non-specific nucleases. Such enhanced stability is a key requirement for DNA nanostructures to be useful as delivery vehicles.
摘要
核酸酶发挥催化功能的能力取决于靶 DNA 底物的序列和结构特征。由于其大小和形状，几个 DNA 四面体能够抵抗特定和非特定核酸酶的作用。这种增强的稳定性是 DNA 纳米结构作为递送载体有用的关键要求。
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