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髋关节发育不良:普遍行超声筛查还是选择性筛查?

Developmental dysplasia of the hip: universal or selective ultrasound screening?

机构信息

Department of Neonatology, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074.

出版信息

Ann Acad Med Singap. 2008 Dec;37(12 Suppl):101-3.

Abstract

Developmental dysplasia of the hip (DDH) is an intriguing condition that evolves during infancy. It would be thus foolhardy to expect a screening tool at birth to be both highly sensitive and specific. Uncertainty regarding an optimal screening method is compounded by a general lack of sound epidemiological data. Clinical screening remains widely used. Some reports estimated that it did not pick up 60% of children who eventually needed surgery. Ultrasonography, it was hoped, would improve detection rates. There are 2 approaches to ultrasound; universal screening, which is adopted by some European countries, or selective screening of high risk infants. The problems with universal ultrasound screening are high false positive rates and high costs. The benefit was a possible 6- to 10-fold reduction in surgery for late DDH. Similar reductions though had also been reported if ultrasound was used selectively for infants with clinical and historical risk factors. A literature review on this topic is presented. There are pros and cons for both screening strategies. This is reflected in the different protocols that exist among various countries. For healthcare systems that are considering their options, universal ultrasound screening is generally not cost-effective and should not be the preferred screening strategy.

摘要

发育性髋关节发育不良(DDH)是一种在婴儿期发展的有趣病症。因此,期望在出生时使用的筛查工具具有高度敏感性和特异性是不明智的。由于缺乏可靠的流行病学数据,对最佳筛查方法的不确定性更加复杂。临床筛查仍然广泛使用。一些报告估计,它没有发现最终需要手术的 60%的儿童。人们希望超声检查能提高检出率。有两种超声方法;一些欧洲国家采用的普遍筛查,或高危婴儿的选择性筛查。超声普遍筛查存在的问题是假阳性率高和成本高。其益处是对晚期 DDH 的手术可能减少 6 至 10 倍。如果对有临床和病史危险因素的婴儿选择性使用超声,也有类似的减少报告。本文对这一主题进行了文献回顾。两种筛查策略都有利有弊。这反映在不同国家之间存在的不同方案中。对于正在考虑选择的医疗保健系统来说,超声普遍筛查通常没有成本效益,不应作为首选的筛查策略。

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