Müller W, Afra D, Schröder R
Acta Neurochir (Wien). 1977;39(1-2):15-25. doi: 10.1007/BF01405237.
On the basis of a three stage grading system we report 23 stage one recurrent oligodendrogliomas (O 1), and 29 stage two recurrent oligodendrogliomas (O 2). In the O 1 group after the first interval 15 became O 2 and 2 became glioblastomas. Twenty tumours of the O 2 group after the first interval were not changed, three became oligodendroglioma-astrocytomas stage 2, and six became glioblastomas. The time relation for the recurrent phase in the primary O 1 group is calculated as 42 months, and in the primary O 2 group as 22 months, but this is without significance. For the development of malignancy, especially for the change to glioblastoma, a prominent participation by transformed local astrocytes seems to be essential. Postoperative irradiation most probably does not favour malignant change. A prolongation of the expectation of life by radiotherapy is not noticed.
基于一个三阶段分级系统，我们报告了23例一期复发性少突胶质细胞瘤（O 1）和29例二期复发性少突胶质细胞瘤（O 2）。在O 1组中，第一次间隔期后15例变为O 2，2例变为胶质母细胞瘤。O 2组的20个肿瘤在第一次间隔期后未发生变化，3例变为2期少突胶质细胞瘤-星形细胞瘤，6例变为胶质母细胞瘤。原发性O 1组复发期的时间关系计算为42个月，原发性O 2组为22个月，但这并无统计学意义。对于恶性肿瘤的发展，尤其是向胶质母细胞瘤的转变，似乎转化的局部星形细胞的显著参与至关重要。术后放疗很可能不利于恶性转变。未观察到放疗能延长预期寿命。
