Lee Chiu Fan
Physics Department, Clarendon Laboratory, Oxford University, Parks Road, Oxford OX1 3PU, United Kingdom.
Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Sep;80(3 Pt 1):031902. doi: 10.1103/PhysRevE.80.031902. Epub 2009 Sep 9.
We carry out a theoretical study on the isotropic-nematic phase transition and phase separation in amyloid fibril solutions. Borrowing the thermodynamic model employed in the study of cylindrical micelles, we investigate the variations in the fibril length distribution and phase behavior with respect to changes in the protein concentration, fibril's rigidity, and binding energy. We then relate our theoretical findings to the nematic ordering experimentally observed in Hen Lysozyme fibril solution.
我们对淀粉样纤维溶液中的各向同性-向列相转变和相分离进行了理论研究。借鉴圆柱状胶束研究中使用的热力学模型，我们研究了纤维长度分布和相行为随蛋白质浓度、纤维刚性和结合能变化的情况。然后，我们将理论研究结果与在溶菌酶纤维溶液中实验观察到的向列有序性联系起来。
