Del Corso Marco, Sammartino Gilberto, Dohan Ehrenfest David M
J Periodontol. 2009 Nov;80(11):1694-7; author reply 1697-9. doi: 10.1902/jop.2009.090253.
Choukroun's platelet-rich fibrin (PRF) is a fibrin biomaterial with a specific composition, three-dimensional architecture, and associated biology. This letter highlights some key issues related to the use of this complex material during periodontal surgery. First, a reproducible protocol for the production of PRF membranes must be followed to control the quantity and quality of the fibrin matrix, leukocytes, platelets, and growth factors. Second, its use in periodontology must follow two principles founded on tissue-engineering basic rules and classical periodontal concepts. Using this two-principle safe protocol, the use of PRF in periodontal surgery leads to a significant improvement during the early healing phase and to a thick and stable final remodeled gingiva.
舒克伦富血小板纤维蛋白（PRF）是一种具有特定成分、三维结构及相关生物学特性的纤维蛋白生物材料。本文强调了在牙周手术中使用这种复杂材料的一些关键问题。首先，必须遵循可重复的PRF膜制备方案，以控制纤维蛋白基质、白细胞、血小板和生长因子的数量和质量。其次，其在牙周病学中的应用必须遵循基于组织工程基本规则和经典牙周概念的两个原则。采用这种双原则安全方案，PRF在牙周手术中的应用可在早期愈合阶段带来显著改善，并形成厚且稳定的最终重塑牙龈。
