Department of Pediatrics, University of California, San Diego School of Medicine, San Diego, California, USA.
Nutr Rev. 2009 Nov;67 Suppl 2:S183-91. doi: 10.1111/j.1753-4887.2009.00239.x.
Human milk oligosaccharides (HMO) are complex glycans that are present at very high concentrations in human milk but not in infant formula. The significant energy expended by mothers to make these complex glycans suggests they must be important. How do maternal HMOs benefit the breast-fed infant? How are HMOs synthesized in the human mammary gland? How can we provide formula-fed infants with HMOs or HMO-like glycans? This article reviews current knowledge and open questions on the biosynthesis and functions of HMOs.
人乳寡糖(HMO)是存在于人乳中而不存在于婴儿配方奶粉中的复杂糖。母亲为合成这些复杂糖而消耗了大量的能量,这表明它们一定很重要。那么,母体 HMO 对母乳喂养的婴儿有什么益处?HMO 是如何在人乳腺中合成的?我们如何为配方奶喂养的婴儿提供 HMO 或 HMO 类似糖?本文综述了 HMO 生物合成和功能的现有知识和悬而未决的问题。