King's College London, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, Room 3.14, Weston Education Centre, 10 Cutcombe Road, London, SE5 9RJ, UK.
Psychiatry Res. 2009 Dec 30;174(3):202-9. doi: 10.1016/j.pscychresns.2009.05.002. Epub 2009 Nov 10.
People with obsessive-compulsive disorder (OCD) have abnormalities in cognitive and motor inhibition, and it has been proposed that these are related to dysfunction of fronto-striatal circuits. However, nobody has investigated neuro-functional abnormalities during a range of inhibition tasks in adults with OCD. The aims of the study were to compare brain activation of people with OCD and controls during three tasks of inhibitory control. Ten unmedicated adults with OCD and 11 healthy controls performed three different tasks of motor and cognitive inhibitory control during event-related functional magnetic resonance imaging: a Go/No-go task (motor inhibition), a motor Stroop task (interference inhibition) and a Switch task (cognitive flexibility). People with OCD displayed significantly different patterns of brain activation compared to controls during all three tasks. During the Go/No-go and Switch experiments, people with OCD had underactivation in task-relevant orbitofrontal/dorsolateral prefrontal, striatal and thalamic regions. During the motor Stroop and Switch tasks, people with OCD also displayed underactivation in temporo-parietal areas. In the Go/No-go and motor Stroop tasks the OCD group showed increased activation compared to controls in cerebellum and predominantly posterior brain regions. OCD is associated with task-relevant fronto-striatal dysfunction during motor inhibition and cognitive switching. In addition, parieto-temporal dysfunction was observed during tasks with a higher attentional load.
强迫症（OCD）患者的认知和运动抑制存在异常，有人提出这些异常与额纹状体回路的功能障碍有关。然而，目前尚未有研究调查强迫症患者在一系列抑制任务中神经功能的异常。本研究旨在比较强迫症患者和对照组在三种抑制控制任务中的大脑激活情况。10 名未用药的强迫症患者和 11 名健康对照组在事件相关功能磁共振成像期间执行了三种不同的运动和认知抑制控制任务：Go/No-go 任务（运动抑制）、运动 Stroop 任务（干扰抑制）和 Switch 任务（认知灵活性）。与对照组相比，强迫症患者在所有三种任务中大脑激活模式均存在显著差异。在 Go/No-go 和 Switch 实验中，强迫症患者在与任务相关的眶额/背外侧前额叶、纹状体和丘脑区域存在激活不足。在运动 Stroop 和 Switch 任务中，强迫症患者还显示颞顶叶区域的激活不足。在 Go/No-go 和运动 Stroop 任务中，与对照组相比，强迫症组在小脑和主要后脑区域显示出更高的激活。强迫症与运动抑制和认知转换过程中的与任务相关的额纹状体功能障碍有关。此外，在注意力负荷较高的任务中还观察到了顶颞叶功能障碍。
