Bilge Şair Yaşan, Şair Ahmet
Department of Psychiatry, Aydın Adnan Menderes University, School of Medicine, Aydın, Turkey.
Department of Neurology, Aydın Adnan Menderes University, School of Medicine, Aydın, Turkey.
Psychiatry Clin Psychopharmacol. 2022 Sep 1;32(3):222-228. doi: 10.5152/pcp.2022.21129. eCollection 2022 Sep.
Mild cognitive impairment is considered a prodromal state and a risk factor for dementia. To the best of our knowledge, no previous studies have examined the relationship between obsessive-compulsive disorder and mild cognitive impairment. One of the risk factors for the development of mild cognitive impairment may be obsessive-compulsive disorder. In this study, we hypothesized that the patients with mild cognitive impairment had a significantly higher rate of obsessive-compulsive disorder than healthy elders, and some types of preexisting obsessive-compulsive symptoms may be associated with mild cognitive impairment.
A total of 66 subjects (mild cognitive impairment = 35; healthy elderly = 31) were assessed for severity of cognitive impairment using the Mini-Mental State Examination, Clinical Dementia Rating Scale, and Addenbrooke's Cognitive Examination III tests. Lifetime diagnosis of obsessive-compulsive disorder was assessed through Structured Clinical Interview of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Axis I disorders. The severity of the obsessive-compulsive disorder and the content of previous obsessive-compulsive symptoms were measured by Yale-Brown Obsessive-Compulsive Scale.
Mild cognitive impairment patients had more previous depressive episodes and a lifetime diagnosis of obsessive-compulsive disorder when compared with healthy subjects, = .023. Educational level was significantly lower in mild cognitive impairment patients than in healthy elders, = .037. The contamination obsessions and cleaning and checking compulsions were significantly higher in the patients with mild cognitive impairment than in healthy subjects, = .044. Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores were significantly higher in patients with mild cognitive impairment, = .009 and = .045 respectively. Lower educational level, previous obsessive-compulsive disorder, Hamilton Anxiety Rating Scale and Hamilton Depression Rating Scale scores, and checking compulsions significantly predicted the patients with mild cognitive impairment, = .044.
Our findings may demonstrate that lower educational level, previous obsessive-compulsive disorder, checking compulsions, and current anxiety and depression severity appeared significantly associated with mild cognitive impairment. We suggest that previous obsessive-compulsive disorder and checking obsessive-compulsive symptoms may be related to earlier stages of memory dysfunction.
轻度认知障碍被认为是一种前驱状态和痴呆的危险因素。据我们所知，以前没有研究探讨过强迫症与轻度认知障碍之间的关系。强迫症可能是轻度认知障碍发生的危险因素之一。在本研究中，我们假设轻度认知障碍患者的强迫症发病率显著高于健康老年人，并且某些类型的既往强迫症状可能与轻度认知障碍有关。
共有66名受试者（轻度认知障碍组 = 35名；健康老年人组 = 31名）使用简易精神状态检查表、临床痴呆评定量表和Addenbrooke认知检查III测试评估认知障碍的严重程度。通过《精神障碍诊断与统计手册》第四版轴I障碍的结构化临床访谈评估强迫症的终生诊断。强迫症的严重程度和既往强迫症状的内容通过耶鲁-布朗强迫量表进行测量。
与健康受试者相比，轻度认知障碍患者有更多的既往抑郁发作和强迫症的终生诊断，P = 0.023。轻度认知障碍患者的教育水平显著低于健康老年人，P = 0.037。轻度认知障碍患者的污染强迫观念以及清洗和检查强迫行为显著高于健康受试者，P = 0.044。轻度认知障碍患者的汉密尔顿焦虑量表和汉密尔顿抑郁量表得分显著更高，分别为P = 0.009和P = 0.045。较低的教育水平、既往强迫症、汉密尔顿焦虑量表和汉密尔顿抑郁量表得分以及检查强迫行为显著预测了轻度认知障碍患者，P = 0.044。
我们的研究结果可能表明，较低的教育水平、既往强迫症、检查强迫行为以及当前的焦虑和抑郁严重程度似乎与轻度认知障碍显著相关。我们认为既往强迫症和检查强迫症状可能与记忆功能障碍的早期阶段有关。
