Hampton Thomas G, Amende Ivo
Mouse Specifics, Inc., Boston, Massachusetts, USA.
J Mot Behav. 2010 Jan-Feb;42(1):1-4. doi: 10.1080/00222890903272025.
Guillot, Asress, Richardson, Glass, and Miller (2008) recently reported that treadmill gait analysis does not detect motor deficits in animal models of Parkinson's disease (PD) or amyotrophic lateral sclerosis (ALS). The authors studied aged C57BL/6J mice administered the neurotoxin 1-methyl 4-phenyl 1-, 2-, 3-, 6-tetrahydropyridine to model PD, and a small number of presymptomatic superoxide dismutase 1 G93A mice to study ALS. Several key issues merit discussion to put their observations in perspective. An increasing number of research groups are applying treadmill gait analysis to their rodent models of numerous movement disorders. The conclusions Guillot et al. drew undermine the potential importance of the paradigm of treadmill gait analysis for understanding and treating PD and ALS.
吉约、阿斯雷斯、理查森、格拉斯和米勒（2008年）最近报告称，跑步机步态分析无法检测出帕金森病（PD）或肌萎缩侧索硬化症（ALS）动物模型中的运动缺陷。作者研究了给予神经毒素1-甲基-4-苯基-1,2,3,6-四氢吡啶以模拟帕金森病的老年C57BL/6J小鼠，以及少量用于研究肌萎缩侧索硬化症的症状前超氧化物歧化酶1 G93A小鼠。有几个关键问题值得讨论，以便正确看待他们的观察结果。越来越多的研究小组正在将跑步机步态分析应用于他们众多运动障碍的啮齿动物模型。吉约等人得出的结论削弱了跑步机步态分析范式对于理解和治疗帕金森病和肌萎缩侧索硬化症的潜在重要性。
