血管化骨髓移植（VBMT）：在未修饰受体中诱导稳定的混合T细胞嵌合体和移植耐受。
Vascularized bone marrow transplantation (VBMT): induction of stable mixed T-cell chimerism and transplantation tolerance in unmodified recipients.
作者信息
Yazdi B, Patel M P, Ramsamooj R, Llull R, Achauer B M, Black K S, Hewitt C W
机构信息
Department of Surgery, University of California, Irvine 92717.
出版信息
Transplant Proc. 1991 Feb;23(1 Pt 1):739-40.
In this preliminary report, our model of VBMT across a semiallogeneic barrier consistently brings about antigen-specific host tolerance with absence of GVHD in the majority of recipients. No immunologic or radiologic intervention was utilized. These results emphasized a potentially important mechanism for low-level stable mixed lymphoid chimerism (SMLC) in tolerance induction, independent of immune suppressive effects due to irradiation or immunopharmacologic intervention.
在本初步报告中，我们跨越半同种异体屏障的VBMT模型在大多数受体中持续诱导出抗原特异性宿主耐受，且无移植物抗宿主病（GVHD）发生。未采用免疫或放射学干预措施。这些结果强调了低水平稳定混合淋巴细胞嵌合体（SMLC）在耐受诱导中的一个潜在重要机制，该机制独立于辐射或免疫药理学干预所产生的免疫抑制作用。
Zotero 插件