文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期,新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

欧洲生物信息学研究所的基因表达图谱。

Gene expression atlas at the European bioinformatics institute.

机构信息

European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.

出版信息

Nucleic Acids Res. 2010 Jan;38(Database issue):D690-8. doi: 10.1093/nar/gkp936. Epub 2009 Nov 11.


DOI:10.1093/nar/gkp936
PMID:19906730
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2808905/
Abstract

The Gene Expression Atlas (http://www.ebi.ac.uk/gxa) is an added-value database providing information about gene expression in different cell types, organism parts, developmental stages, disease states, sample treatments and other biological/experimental conditions. The content of this database derives from curation, re-annotation and statistical analysis of selected data from the ArrayExpress Archive of Functional Genomics Data. A simple interface allows the user to query for differential gene expression either (i) by gene names or attributes such as Gene Ontology terms, or (ii) by biological conditions, e.g. diseases, organism parts or cell types. The gene queries return the conditions where expression has been reported, while condition queries return which genes are reported to be expressed in these conditions. A combination of both query types is possible. The query results are ranked using various statistical measures and by how many independent studies in the database show the particular gene-condition association. Currently, the database contains information about more than 200,000 genes from nine species and almost 4500 biological conditions studied in over 30,000 assays from over 1000 independent studies.

摘要

基因表达图谱(http://www.ebi.ac.uk/gxa)是一个增值型数据库,提供了不同细胞类型、生物部位、发育阶段、疾病状态、样本处理和其他生物/实验条件下的基因表达信息。该数据库的内容源自对功能基因组学数据档案 ArrayExpress 中精选数据的注释、重新注释和统计分析。一个简单的界面允许用户通过基因名称或基因本体论术语等属性,或者通过生物条件(如疾病、生物部位或细胞类型)查询差异基因表达。基因查询返回报告表达的条件,而条件查询返回在这些条件下报告表达的基因。可以同时使用这两种查询类型。查询结果使用各种统计措施和数据库中显示特定基因-条件关联的独立研究数量进行排序。目前,该数据库包含了来自 9 个物种的 20 多万个基因的信息,以及在 1000 多项独立研究的 3 万多个实验中研究过的近 4500 个生物条件的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c147/2808905/0e34d459ee56/gkp936f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c147/2808905/2ea038934be4/gkp936f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c147/2808905/08fbadd73f6a/gkp936f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c147/2808905/eceb6387df2b/gkp936f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c147/2808905/739b1a25263e/gkp936f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c147/2808905/0e34d459ee56/gkp936f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c147/2808905/2ea038934be4/gkp936f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c147/2808905/08fbadd73f6a/gkp936f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c147/2808905/eceb6387df2b/gkp936f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c147/2808905/739b1a25263e/gkp936f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c147/2808905/0e34d459ee56/gkp936f5.jpg

相似文献

[1]
Gene expression atlas at the European bioinformatics institute.

Nucleic Acids Res. 2009-11-11

[2]
Gene Expression Atlas update--a value-added database of microarray and sequencing-based functional genomics experiments.

Nucleic Acids Res. 2011-11-7

[3]
The European Bioinformatics Institute's data resources.

Nucleic Acids Res. 2009-11-24

[4]
Atlas - a data warehouse for integrative bioinformatics.

BMC Bioinformatics. 2005-2-21

[5]
Archiving next generation sequencing data.

Nucleic Acids Res. 2009-12-3

[6]
Expression Atlas update--a database of gene and transcript expression from microarray- and sequencing-based functional genomics experiments.

Nucleic Acids Res. 2013-12-4

[7]
ArrayExpress update--from an archive of functional genomics experiments to the atlas of gene expression.

Nucleic Acids Res. 2009-1

[8]
BioSamples database: an updated sample metadata hub.

Nucleic Acids Res. 2019-1-8

[9]
The Gene Ontology in 2010: extensions and refinements.

Nucleic Acids Res. 2009-11-17

[10]
GOrilla: a tool for discovery and visualization of enriched GO terms in ranked gene lists.

BMC Bioinformatics. 2009-2-3

引用本文的文献

[1]
Identification of a Novel GRM1 Frameshift Variant in Two Pakistani Families Broadens the Genetic Landscape of Ultra-Rare Spinocerebellar Ataxia Type 13.

Cerebellum. 2025-8-27

[2]
GrameneOryza: a comprehensive resource for Oryza genomes, genetic variation, and functional data.

Database (Oxford). 2025-4-4

[3]
The rate and spectrum of new mutations in mice inferred by long-read sequencing.

Genome Res. 2025-1-22

[4]
Unraveling the role of cloud computing in health care system and biomedical sciences.

Heliyon. 2024-4-2

[5]
Unveiling Prognostic RNA Biomarkers through a Multi-Cohort Study in Colorectal Cancer.

Int J Mol Sci. 2024-3-14

[6]
Severe Neurodevelopmental Disorder in Autosomal Recessive Spinocerebellar Ataxia 13 (SCAR13) Caused by Two Novel Frameshift Variants in GRM1.

Cerebellum. 2024-10

[7]
Predicting gene expression divergence between single-copy orthologs in two species.

Genome Biol Evol. 2023-5-12

[8]
RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function.

Nat Commun. 2023-4-20

[9]
Genetic Variant in Underlies Congenital Cerebellar Ataxia with No Obvious Intellectual Disability.

Int J Mol Sci. 2023-1-12

[10]
Temporal progress of gene expression analysis with RNA-Seq data: A review on the relationship between computational methods.

Comput Struct Biotechnol J. 2022-12-1

本文引用的文献

[1]
Genevestigator v3: a reference expression database for the meta-analysis of transcriptomes.

Adv Bioinformatics. 2008

[2]
Ensembl 2009.

Nucleic Acids Res. 2009-1

[3]
ArrayExpress update--from an archive of functional genomics experiments to the atlas of gene expression.

Nucleic Acids Res. 2009-1

[4]
NCBI GEO: archive for high-throughput functional genomic data.

Nucleic Acids Res. 2009-1

[5]
The Universal Protein Resource (UniProt) 2009.

Nucleic Acids Res. 2009-1

[6]
Overview and utilization of the NCI thesaurus.

Comp Funct Genomics. 2004

[7]
ChEBI: a database and ontology for chemical entities of biological interest.

Nucleic Acids Res. 2008-1

[8]
Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles.

Neoplasia. 2007-2

[9]
ArrayExpress service for reviewers/editors of DNA microarray papers.

Nat Biotechnol. 2006-11

[10]
A reference ontology for biomedical informatics: the Foundational Model of Anatomy.

J Biomed Inform. 2003-12

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索