European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.
Nucleic Acids Res. 2010 Jan;38(Database issue):D690-8. doi: 10.1093/nar/gkp936. Epub 2009 Nov 11.
The Gene Expression Atlas (http://www.ebi.ac.uk/gxa) is an added-value database providing information about gene expression in different cell types, organism parts, developmental stages, disease states, sample treatments and other biological/experimental conditions. The content of this database derives from curation, re-annotation and statistical analysis of selected data from the ArrayExpress Archive of Functional Genomics Data. A simple interface allows the user to query for differential gene expression either (i) by gene names or attributes such as Gene Ontology terms, or (ii) by biological conditions, e.g. diseases, organism parts or cell types. The gene queries return the conditions where expression has been reported, while condition queries return which genes are reported to be expressed in these conditions. A combination of both query types is possible. The query results are ranked using various statistical measures and by how many independent studies in the database show the particular gene-condition association. Currently, the database contains information about more than 200,000 genes from nine species and almost 4500 biological conditions studied in over 30,000 assays from over 1000 independent studies.
基因表达图谱(http://www.ebi.ac.uk/gxa)是一个增值型数据库,提供了不同细胞类型、生物部位、发育阶段、疾病状态、样本处理和其他生物/实验条件下的基因表达信息。该数据库的内容源自对功能基因组学数据档案 ArrayExpress 中精选数据的注释、重新注释和统计分析。一个简单的界面允许用户通过基因名称或基因本体论术语等属性,或者通过生物条件(如疾病、生物部位或细胞类型)查询差异基因表达。基因查询返回报告表达的条件,而条件查询返回在这些条件下报告表达的基因。可以同时使用这两种查询类型。查询结果使用各种统计措施和数据库中显示特定基因-条件关联的独立研究数量进行排序。目前,该数据库包含了来自 9 个物种的 20 多万个基因的信息,以及在 1000 多项独立研究的 3 万多个实验中研究过的近 4500 个生物条件的信息。
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