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2010 年的基因本体论:扩展和改进。

The Gene Ontology in 2010: extensions and refinements.

出版信息

Nucleic Acids Res. 2010 Jan;38(Database issue):D331-5. doi: 10.1093/nar/gkp1018. Epub 2009 Nov 17.

DOI:10.1093/nar/gkp1018
PMID:19920128
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2808930/
Abstract

The Gene Ontology (GO) Consortium (http://www.geneontology.org) (GOC) continues to develop, maintain and use a set of structured, controlled vocabularies for the annotation of genes, gene products and sequences. The GO ontologies are expanding both in content and in structure. Several new relationship types have been introduced and used, along with existing relationships, to create links between and within the GO domains. These improve the representation of biology, facilitate querying, and allow GO developers to systematically check for and correct inconsistencies within the GO. Gene product annotation using GO continues to increase both in the number of total annotations and in species coverage. GO tools, such as OBO-Edit, an ontology-editing tool, and AmiGO, the GOC ontology browser, have seen major improvements in functionality, speed and ease of use.

摘要

GO 联盟(http://www.geneontology.org)(GOC)继续开发、维护和使用一套结构化、受控的词汇表,用于注释基因、基因产物和序列。GO 本体论在内容和结构上都在不断扩展。已经引入并使用了几种新的关系类型,以及现有的关系,以在 GO 域之间和内部创建链接。这些改进了生物学的表示方式,促进了查询,并允许 GO 开发人员系统地检查和纠正 GO 中的不一致性。使用 GO 的基因产物注释在注释总数和物种覆盖率方面都在不断增加。GO 工具,如本体编辑工具 OBO-Edit 和 GOC 本体浏览器 AmiGO,在功能、速度和易用性方面都有了重大改进。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d27/2808930/0eb122c3cbe7/gkp1018f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d27/2808930/0eb122c3cbe7/gkp1018f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d27/2808930/0eb122c3cbe7/gkp1018f1.jpg

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